Effects of Contralateral Noise on 40-Hz and 80-Hz Auditory Steady-State Responses
Effects of Contralateral Noise on 40-Hz and 80-Hz Auditory Steady-State Responses
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DOI：
10.1097/aud.0b013e3181acfb57
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发表时间：
2009-10-01
期刊：
影响因子：
3.7
通讯作者：
Kobayashi, Toshimitsu
中科院分区：
文献类型：
--
作者：
Maki, Atsuko;Kawase, Tetsuaki;Kobayashi, Toshimitsu
目的：如果对侧施加40至60分贝的白噪声，40赫兹听觉稳态响应（ASSR）的振幅在45至60分贝的水平下响应于重复的点击或音调点，则通过中央掩蔽机制减少高达50%。然而，对侧噪声对ASSR阈值升高的影响尚不清楚。本研究探讨了对侧噪声对临床检查中广泛使用的40 hz和80 hz调幅音调的ASSR阈值测量的影响。设计：在11名健康志愿者（110名男性和1名女性，平均年龄26.1岁）中，研究了对侧噪声对500 Hz和2000 Hz调幅音调的40和80 Hz assr的影响。在载波频率为500 Hz和2000 Hz的ASSR测量中，对侧噪声分别由700 Hz和4000 Hz低通滤波的白噪声组成。结果：对侧噪声40 dB SL水平未引起心理生理阈值显著升高，引起40 hz ASSR阈值显著升高（平均10 ~ 15 dB），引起80 hz ASSR阈值无显著升高。结论：对40 hz和80 hz ASSR的不同影响可能与来源的差异有关，因为40 hz ASSR包含更多来自上听通路的成分，这些成分受对侧掩蔽影响，而80 hz ASSR包含更多来自脑干的成分。目前的结果表明，在使用双耳声音呈现的临床测量中，40-Hz ASSR阈值可能出现升高，并导致心理物理阈值与40-Hz ASSR测量值之间可能存在差异。
Objectives: The amplitude of 40-Hz auditory steady-state response (ASSR) in response to repeated click or tone pips at levels of 45 to 60 dB SL is reduced by up to 50% by the central masking mechanism if white noise at levels of 40 to 60 dB SL is applied contralaterally. However, the effect of contralateral noise on the elevation of the threshold of ASSR is unknown. The present study investigated the effects of contralateral noise on the threshold measurements of ASSR for 40- and 80-Hz amplitude modulated tones that are widely used in clinical examinations.Design: The effects of contralateral noise on the 40- and 80-Hz ASSRs for amplitude modulated tones at 500 Hz and 2000 Hz were examined in 11 healthy volunteers (110 men and 1 woman, mean age 26.1 years). Contralateral noise consisted of white noise low-pass filtered at 700 and 4000 Hz in the measurements of ASSR at a carrier frequency of 500 and 2000 Hz, respectively.Results: Contralateral noise at a level of 40 dB SL caused no significant psychophysical threshold elevation, caused significant threshold elevation of the 40-Hz ASSR (average 10 to 15 dB), and caused no significant threshold elevation of the 80-Hz ASSR.Conclusions: The different effects on the 40- and 80-Hz ASSRs were probably related to the differences in sources because the 40-Hz ASSR contains more components from the upper auditory pathway that are affected by contralateral masking, whereas the 80-Hz ASSR contains more components from the brain stem. The present results suggest that threshold elevation of the 40-Hz ASSR may occur during clinical measurements using binaural presentation of sounds and cause a possible discrepancy between psychophysical threshold and 40-Hz ASSR measurements.