Circulating leptin in patients with chronic obstructive pulmonary disease
Circulating leptin in patients with chronic obstructive pulmonary disease
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DOI：
10.1164/ajrccm.159.4.9806134
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发表时间：
1999-04-01
影响因子：
24.7
通讯作者：
Tomoike, H
中科院分区：
文献类型：
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作者：
Takabatake, N;Nakamura, H;Tomoike, H
不明原因的体重减轻在慢性阻塞性肺疾病（COPD）患者中很常见。由于瘦素是一种肥胖基因产物，已知在控制体重和能量消耗方面起重要作用，我们研究了31例COPD患者和15例年龄匹配的健康对照者的血清瘦素水平，沿着循环肿瘤坏死因子-α（TNF-α）和可溶性TNF受体（sTNF-R55和R75）水平。COPD患者的体重指数（BMI）和体脂百分比（%fat）显著低于健康对照组（BMI = 18.1 +/- 2.7 kg/m2对比22.8 +/- 2.2 kg/m2 [平均值+/- SD]; p < 0.0001; %脂肪= 16.9 +/- 5.8%对比24.3 +/- 4.9%; p < 0.001）。COPD患者的血清瘦素水平显着低于健康对照组（1.14 +/- 1.17 ng/ml vs 2.47 +/- 2.01 ng/ml; p < 0.05）。相反，血清TNF-α水平（6.59 +/- 1.92 pg/ml对比5.41 +/- 1.60 pg/ml; p < 0.05），血浆sTNF-R55（1.16 +/- 0.47 ng/ml对比0.67 +/- 0.13 ng/ml; p < 0.0001）和sTNF-R75 COPD患者的水平（3.65 +/- 1.29 ng/ml vs 2.25 +/- 0.43 ng/ml; p < 0.0001）显着高于健康对照组。重要的是，循环瘦素水平（对数转换）确实与BMI和%脂肪相关，但与COPD患者的TNF-α或sTNF-R水平无关。这些数据表明，循环中的瘦素是独立的TNF-α系统和调节生理，即使在恶病质的COPD患者的存在。
Unexplained weight loss is common in patients with chronic obstructive pulmonary disease (COPD). Since leptin, an obesity gene product, is known to play important roles in the control of body weight and energy expenditure, we investigated serum leptin levels, along with circulating tumor necrosis factor-alpha (TNF-alpha) and soluble TNF receptor (sTNF-R55 and R75) levels, in 31 patients with COPD and 15 age-matched healthy controls. The body mass index (BMI) and percent body fat (%fat) were significantly lower in the COPD patients than in the healthy controls (BMI = 18.1 +/- 2.7 kg/m(2) versus 22.8 +/- 2.2 kg/m(2) [mean +/- SD]; p < 0.0001; %fat = 16.9 +/- 5.8% versus 24.3 +/- 4.9%; p < 0.001). Serum leptin levels were significantly lower in the COPD patients than in the healthy controls (1.14 +/- 1.17 ng/ml versus 2.47 +/- 2.01 ng/ml; p < 0.05). In contrast, serum TNF-alpha levels (6.59 +/- 1.92 pg/ml versus 5.41 +/- 1.60 pg/ml; p < 0.05), plasma sTNF-R55 (1.16 +/- 0.47 ng/ml versus 0.67 +/- 0.13 ng/ml; p < 0.0001) and sTNF-R75 (3.65 +/- 1.29 ng/ml versus 2.25 +/- 0.43 ng/ml; p < 0.0001) levels were significantly higher in the COPD patients than in the healthy controls. Importantly, circulating leptin levels (log transformed) did correlate well with BMI and %fat, but not with TNF-alpha or with sTNF-R levels in the COPD patients. These data suggest that circulating leptin is independent of the TNF-alpha system and is regulated physiologically even in the presence of cachexia in patients with COPD.