Pediatric RSV-Associated Hospitalizations Before and During the COVID-19 Pandemic.
Pediatric RSV-Associated Hospitalizations Before and During the COVID-19 Pandemic.
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DOI：
10.1001/jamanetworkopen.2023.36863
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发表时间：
2023-10-02
影响因子：
13.8
通讯作者：
Papenburg, Jesse
中科院分区：
文献类型：
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作者：
Bourdeau, Malou;Vadlamudi, Nirma Khatri;Bastien, Nathalie;Embree, Joanne;Halperin, Scott A.;Jadavji, Taj;Kazmi, Kescha;Langley, Joanne M.;Lebel, Marc H.;Le Saux, Nicole;Moore, Dorothy;Morris, Shaun K.;Pernica, Jeffrey M.;Robinson, Joan;Sadarangani, Manish;Bettinger, Julie A.;Papenburg, Jesse
这项横断面研究调查了新冠肺炎大流行之前和期间儿童和青少年中感染呼吸道合胞病毒的住院比例和相关结局的比率。加拿大儿科呼吸道合胞病毒相关住院的流行病学是什么？随着新冠肺炎大流行，它发生了怎样的变化？这项对11个 014儿科呼吸道合胞病毒相关住院的横断面研究发现，加拿大儿科中心的此类住院非常频繁，特别是在6个月以下的儿童中。在2020-2021年几乎缺席之后，2021-2022年的RSV入院人数与流行前的水平相比有所增加，尽管严重程度和年龄分布保持不变，但RSV活动的时间在区域间差异更大。这项研究发现加拿大儿科中心的RSV住院负担很大，特别是在6个月以下的儿童中。研究发现，在2021-2022年间，由于RSV活动时间的地区差异，入院人数有所增加。呼吸道合胞病毒(RSV)是儿科住院的主要原因。描述2017年至2022年加拿大三级儿科医院儿童和青少年中呼吸道合胞病毒相关住院的流行病学和负担，包括新冠肺炎大流行期间的变化。这项横断面研究是在加拿大免疫监测计划主动(IMPACT)计划的13个儿科三级护理中心进行的5个RSV季节(2017-2018至2021-2022)进行的。住院的0至16岁患有实验室确认的呼吸道合胞病毒感染的儿童和青少年包括在内。计算与呼吸道合胞病毒相关的全原因住院的比例，以及呼吸道合胞病毒住院与重症监护病房(ICU)入院、延长住院(≥7天)和住院死亡率的计数和比例，并按季节、年龄组和地区进行计算。季节性用流行曲线来描述。将2021-2022年的RSV住院人数与2017-2018年至2019-2020年流行前期间的住院人数进行比较。对P值进行Bonferroni校正，以调整多重统计比较。在11例因呼吸道合胞病毒感染而住院的儿童和青少年中(男性6 035例(54.8%)；<6个月5 488例(49.8%))，2 594例(23.6%)入院 ，其中1 576例(60.8%)为6个月以下儿童。中位住院天数(IQR)为4(2-6)天。在流行前期，RSV相关住院的平均(SD)次数为2522次(88.8次)。2020-2021年报告的住院人数为58人，其次是2021-2022年的3170人。与呼吸道合胞病毒相关的全原因住院比例从大流行前的3.2%(95%可信区间，3.1%-3.3%)上升到2021-2022年间的4.5%(95%可信区间，4.3%-4.6%)(差异为1.3个百分点；95%可信区间，1.1-1.5个百分点；修正后的P <； .001)。2021年至2022年，3个省与呼吸道合胞病毒相关的住院率显著增加(差异幅度为2.5个百分点；魁北克省95%CI为1.4-3.6个百分点至2.9个百分点；艾伯塔省95%CI为1.4-3.5个百分点；P <； .001全部校正)。2021-2022年与流行前期相比，年龄、性别、入住ICU、延长住院时间和病死率没有变化。在2021-2022年，RSV季节性的地区间差异加剧，1个省在10月份达到高峰，4个省在12月，3个省在4月或5月。这项研究发现，加拿大儿科医院与RSV相关的住院负担很大，特别是在6个月以下的婴儿中，与流行前时期相比，2021-2022年RSV住院人数增加，而病情严重程度保持不变。这些发现表明，对6个月以下的婴儿采取RSV预防策略将与减少儿童RSV疾病负担有关。
This cross-sectional study investigates proportions of hospital admissions with RSV and rates of associated outcomes among children and adolescents before and during the COVID-19 pandemic. What is the epidemiology of pediatric respiratory syncytial virus (RSV)–associated hospitalizations in Canada, and how has it changed with the COVID-19 pandemic? This cross-sectional study of 11 014 pediatric RSV-associated hospitalizations found that such hospitalizations in Canadian pediatric centers were frequent, particularly among children under age 6 months. After a near absence in 2020-2021, RSV admissions increased in 2021-2022 compared with prepandemic means, while severity and age distribution remained similar but with greater interregional variability in timing of RSV activity. This study found a significant burden of RSV hospitalizations in Canadian pediatric centers, particularly among children under age 6 months. The study found an increase in admissions during 2021-2022, with regional variation in RSV activity timing. Respiratory syncytial virus (RSV) is a leading cause of pediatric hospitalizations. To describe the epidemiology and burden of RSV-associated hospitalizations among children and adolescents in Canadian tertiary pediatric hospitals from 2017 to 2022, including changes during the COVID-19 pandemic. This cross-sectional study was conducted during 5 RSV seasons (2017-2018 to 2021-2022) at 13 pediatric tertiary care centers from the Canadian Immunization Monitoring Program Active (IMPACT) program. Hospitalized children and adolescents aged 0 to 16 years with laboratory-confirmed RSV infection were included. The proportion of all-cause admissions associated with RSV and counts and proportions of RSV hospitalizations with intensive care unit (ICU) admission, prolonged stay (≥7 days), and in-hospital mortality were calculated overall and by season, age group, and region. Seasonality was described using epidemic curves. RSV hospitalizations for 2021-2022 were compared with those in the prepandemic period of 2017-2018 through 2019-2020. Bonferroni corrections were applied to P values to adjust for multiple statistical comparisons. Among 11 014 RSV-associated hospitalizations in children and adolescents (6035 hospitalizations among male patients [54.8%]; 5488 hospitalizations among patients aged <6 months [49.8%]), 2594 hospitalizations (23.6%) had admission to the ICU, of which 1576 hospitalizations (60.8%) were among children aged less than 6 months. The median (IQR) hospital stay was 4 (2-6) days. The mean (SD) number of RSV-associated hospitalizations during prepandemic seasons was 2522 (88.8) hospitalizations. There were 58 hospitalizations reported in 2020-2021, followed by 3170 hospitalizations in 2021-2022. The proportion of all-cause hospitalizations associated with RSV increased from a mean of 3.2% (95% CI, 3.1%-3.3%) before the pandemic to 4.5% (95% CI, 4.3%-4.6%) in 2021-2022 (difference, 1.3 percentage points; 95% CI, 1.1-1.5 percentage points; corrected P < .001). A significant increase in RSV-associated hospitalizations was found in 2021-2022 for 3 provinces (difference range, 2.5 percentage points; 95% CI, 1.4-3.6 percentage points for Quebec to 2.9 percentage points; 95% CI, 1.4-3.5 percentage points for Alberta; all corrected P < .001). Age, sex, ICU admission, prolonged length of stay, and case fatality rate did not change in 2021-2022 compared with the prepandemic period. Interregional differences in RSV seasonality were accentuated in 2021-2022, with peaks for 1 province in October, 4 provinces in December, and 3 provinces in April, or May. This study found that the burden of RSV-associated hospitalizations in Canadian pediatric hospitals was substantial, particularly among infants aged less than 6 months, and RSV hospitalizations increased in 2021-2022 compared with the prepandemic period, while severity of illness remained similar. These findings suggest that RSV preventive strategies for infants aged less than 6 months would be associated with decreased RSV disease burden in children.
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影响因子：
36.4
作者：
Nygaard, Ulrikka;Hartling, Ulla Birgitte;Nielsen, Jens;Vestergaard, Lasse Skafte;Dungu, Kia Hee Schultz;Nielsen, Jeppe Sylvest Angaard;Sellmer, Anna;Matthesen, Astrid Thaarup;Kristensen, Kim;Holm, Mette
通讯作者：
Holm, Mette
DOI：
10.1016/s2213-2600(22)00414-3
发表时间：
2023-04
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
通讯作者：
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DOI：
10.1016/j.lana.2021.100015
发表时间：
2021-09
期刊：
Lancet regional health. Americas
影响因子：
--
作者：
Groves HE;Piché-Renaud PP;Peci A;Farrar DS;Buckrell S;Bancej C;Sevenhuysen C;Campigotto A;Gubbay JB;Morris SK
通讯作者：
Morris SK
影响因子：
11.8
作者：
Ujiie M;Tsuzuki S;Nakamoto T;Iwamoto N
通讯作者：
Iwamoto N
呼吸综合病毒是美国婴儿住院的主要原因，2009 - 2019年：全国（全国）住院样本的研究。
DOI：
10.1093/infdis/jiac120
发表时间：
2022-08-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
通讯作者：
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