A novel rotary pulsatile flow pump for cardiopulmonary bypass.
A novel rotary pulsatile flow pump for cardiopulmonary bypass.
复制标题
一种用于体外循环的新型旋转脉动流泵。
DOI：
10.1097/mat.0000000000000058
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Haft,JonathanW
中科院分区：
文献类型：
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作者：
Teman,NicholasR;Mazur,DanielE;Toomasian,John;Jahangir,Emilia;Alghanem,Fares;Goudie,Marcus;Rojas-Peña,Alvaro;Haft,JonathanW
体外循环（CPB）中搏动血流比连续血流具有上级优越性。然而，由于创建一致的生理脉冲的实用性和复杂性，脉动流（PF）技术的采用受到限制。设计了一种小儿搏动旋转心室泵（PRVP）来解决这个问题。我们在动物模型中评价了PRVP，并确定了其在CPB期间产生PF的能力。在4头仔猪（10-12 kg）中测试PRVP（改进的蠕动泵，泵室出口逐渐变细）。使用右心房和主动脉插管进行插管，并将压力传感器插入股动脉。在不同流量水平下获得压力曲线，并与动物的基线生理功能和CF滚子泵进行比较。在所有测试条件下，与CF相比，PRVP设置中的压力和流量波形显示出显著的脉动性。血流动力学能量数据的测量，包括脉动能量百分比和剩余液压能量，也显示PRVP的脉动性显著增加（p< 0.001）。PRVP产生生理上显著的PF，类似于自体心脏的脉动，并且有可能在儿科CPB中容易实施。
It has been suggested that pulsatile blood flow is superior to continuous flow (CF) in cardiopulmonary bypass (CPB). However, adoption of pulsatile flow (PF) technology has been limited because of practicality and complexity of creating a consistent physiologic pulse. A pediatric pulsatile rotary ventricular pump (PRVP) was designed to address this problem. We evaluated the PRVP in an animal model and determined its ability to generate PF during CPB. The PRVP (modified peristaltic pump, with tapering of the outlet of the pump chamber) was tested in four piglets (10–12 kg). Cannulation was performed with right atrial and aortic cannulae, and pressure sensors were inserted into the femoral arteries. Pressure curves were obtained at different levels of flow and compared with both the animal’s baseline physiologic function and a CF roller pump. Pressure and flow waveforms demonstrated significant pulsatility in the PRVP setup compared with CF at all tested conditions. Measurement of hemodynamic energy data, including the percentage pulsatile energy and the surplus hydraulic energy, also revealed a significant increase in pulsatility with the PRVP (p< 0.001). The PRVP creates physiologically significant PF, similar to the pulsatility of a native heart, and has the potential to be easily implemented in pediatric CPB.