Stimulation of the human motor cortex alters generalization patterns of motor learning.
Stimulation of the human motor cortex alters generalization patterns of motor learning.
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DOI：
10.1523/jneurosci.0273-11.2011
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发表时间：
2011-05-11
期刊：
影响因子：
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通讯作者：
Shadmehr R
中科院分区：
文献类型：
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作者：
Orban de Xivry JJ;Marko MK;Pekny SE;Pastor D;Izawa J;Celnik P;Shadmehr R
有人假设，伴随学习的泛化模式携带着参与学习的神经系统的特征。达到适应力场的泛化模式，建议主要从事的神经系统，编码运动的内在坐标的关节和肌肉，和较少的参与的神经系统，编码运动的外在坐标的任务。在皮质运动区中，内在坐标系统在初级感觉运动皮质中最突出。在这里，我们使用经颅直流电刺激（tDCS）来改变突触可塑性的机制，并发现当它被应用于运动皮层时，它增加了内在坐标的泛化，但不是外在坐标。然而，当tDCS应用于后顶叶皮层，它没有影响学习或概括的力场任务。结果表明，在力场适应，学习的组成部分，产生泛化的内在坐标依赖于可塑性的感觉运动皮层。
It has been hypothesized that the generalization patterns that accompany learning carry the signatures of the neural systems that are engaged in that learning. Reach adaptation in force fields has generalization patterns that suggest primary engagement of a neural system that encodes movements in the intrinsic coordinates of joints and muscles, and lesser engagement of a neural system that encodes movements in the extrinsic coordinates of the task. Among the cortical motor areas, the intrinsic coordinate system is most prominently represented in the primary sensorimotor cortices. Here, we used transcranial direct current stimulation (tDCS) to alter mechanisms of synaptic plasticity and found that when it was applied to the motor cortex, it increased generalization in intrinsic coordinates but not extrinsic coordinates. However, when tDCS was applied to the posterior parietal cortex, it had no effects on learning or generalization in the force field task. The results suggest that during force field adaptation, the component of learning that produces generalization in intrinsic coordinates depends on the plasticity in the sensorimotor cortex.