Decreased expression of Fas (APO-1/CD95) on peripheral blood CD4+T lymphocytes in cutaneous T-cell lymphomas
Decreased expression of Fas (APO-1/CD95) on peripheral blood CD4+T lymphocytes in cutaneous T-cell lymphomas
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DOI：
10.1046/j.1365-2133.2000.03889.x
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发表时间：
2000-12-01
影响因子：
10.3
通讯作者：
Guilhou, JJ
中科院分区：
文献类型：
--
作者：
Dereure, O;Portales, P;Guilhou, JJ
Background The usually protracted and indolent course of cutaneous T-cell lymphoma (CTCL) is consistent with an accumulation of lymphocytes rather than being a true proliferative disorder, perhaps as the result of defective lymphocyte apoptosis. Fas (CD95) is the main signalling membrane molecule involved in postactivation T-lymphocyte apoptosis.Objectives To evaluate expression of Fas on circulating CD4+ lymphocytes in patients with CTCL.Methods Fas expression on peripheral blood CD4+ T cells in 16 patients with mycosis fungoides (patch and infiltrated plaque stages) and in four patients with Sezary syndrome was compared with that in 25 matched patients with lymphocyte-mediated cutaneous benign inflammatory disorders and in 15 subjects without inflammatory cutaneous diseases.Results Fas expression on peripheral CD4+ lymphocytes was significantly lower in patients with CTCL compared with subjects with benign inflammatory cutaneous disorders and with healthy donors.Conclusions This pattern supports the hypothesis that a defect in T-cell apoptosis may play a part in the pathophysiology of CTCL, perhaps through abnormalities of the Fas/Fas ligand system. Alternatively, this decrease could be the result of the presence of the soluble Fas ligand molecule in the sera of patients with CTCL.
