Children's self-reported psychotic symptoms and adult schizophreniform disorder -: A 15-year longitudinal study
Children's self-reported psychotic symptoms and adult schizophreniform disorder -: A 15-year longitudinal study
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DOI：
10.1001/archpsyc.57.11.1053
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发表时间：
2000-11-01
影响因子：
--
通讯作者：
Harrington, H
中科院分区：
文献类型：
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作者：
Poulton, R;Caspi, A;Harrington, H
背景资料：儿童期精神分裂症发展的危险因素已被证明只有适度和非特异性的影响，大多数似乎与成人表型无关。我们报告的第一次直接检查的纵向关系，精神病症状在儿童期和adulty.Methods：我们分析了前瞻性的数据，从出生队列（N=761），其中儿童被问及有关妄想的信念和幻觉的经验，在11岁，然后随访到26岁。结构化的诊断访谈，在这两个年龄和自我报告的精神分裂症样症状增加了其他数据来源在26 years.Results：自我报告的精神病性症状在11岁时预测一个非常高的风险，在26岁的精神分裂症样诊断（优势比，16.4; 95%置信区间，3.9-67.8）。在归因风险方面，队列中42%的26岁精神分裂症样病例在11岁时报告了1种或多种精神病症状。在26岁的时候，精神病性症状不能预测躁狂或抑郁，这表明预测精神分裂症样障碍的特异性。儿童和成人精神病症状之间的联系并不简单的结果，一般儿童期psychopathology.Conclusion：这些研究结果提供了第一个证据的连续性的精神症状从童年到成年。
Background: Childhood risk factors for the development of adult schizophrenia have proved to have only modest and nonspecific effects, and most seem unrelated to the adult phenotype. We report the first direct examination of the longitudinal relationship between psychotic symptoms in childhood and adulthood.Methods: We analyzed prospective data from a birth cohort (N=761), in which children were asked about delusional beliefs and hallucinatory experiences at age 11 years, and then followed up to age 26 years. Structured diagnostic interviews were employed at both ages and self-report of schizophreniform symptoms was augmented by other data sources at age 26 years.Results: Self-reported psychotic symptoms at age 11 years predicted a very high risk of a schizophreniform diagnosis at age 26 years (odds ratio, 16.4; 95% confidence interval, 3.9-67.8). In terms of attributable risk, 42% of the age-26 schizophreniform cases in the cohort had reported 1 or more psychotic symptoms at age 11 years. Age-ii psychotic symptoms did not predict mania or depression at age 26 years, suggesting specificity of prediction to schizophreniform disorder. The link between child and adult psychotic symptoms was not simply the result of general childhood psychopathology.Conclusion: These findings provide the first evidence for continuity of psyche tic symptoms from childhood to adulthood.