Associations between differential leucocyte count and incident coronary heart disease: 1764 incident cases from seven prospective studies of 30 374 individuals
Associations between differential leucocyte count and incident coronary heart disease: 1764 incident cases from seven prospective studies of 30 374 individuals
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DOI：
10.1016/j.ehj.2004.05.002
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发表时间：
2004-08-01
影响因子：
39.3
通讯作者：
Danesh, J
中科院分区：
文献类型：
--
作者：
Wheeler, JG;Mussolino, ME;Danesh, J
在一项前瞻性队列研究中，我们旨在评估不同白细胞成分与冠心病（CHD）之间的潜在关联，并将这些发现与其他相关前瞻性研究结合起来进行荟萃分析。方法和结果我们报告了来自第一次国家健康和营养调查（NHANES 1）和NHANES 1流行病学随访研究（NHEFS）的差异白细胞计数和冠心病的数据，涉及4625个人，平均随访18年。NHEFS涉及914例冠心病事件，并将中性粒细胞计数前三分之一与后三分之一的人群进行比较，得出调整后的风险比为1.09（0.93-1.29）。在一项涉及NHEFS和其他四项研究的荟萃分析中，共有1764例冠心病病例，中性粒细胞计数与冠心病的相关性强于与其他特定白细胞成分的相关性（综合风险比= 1.33[1.17-1.50]），但单独研究之间存在实质性的异质性（chi(2) = 18.0, p < 0.001）。结论：尽管目前的合成提供了迄今为止对冠心病中特定白细胞成分的最全面的评估，但还需要额外的前瞻性数据来确定中性粒细胞是否对冠心病有影响。计数比其他成分更能预测冠心病风险。(C) 2004欧洲心脏病学会。Elsevier Ltd.出版。版权所有。
Aims We aimed to assess potential associations between different leucocyte components and coronary heart disease (CHD) in a prospective cohort study, and to put these findings in context of other relevant prospective studies in a meta-analysis.Methods and results We report data on differential leucocyte count and CHD derived from the first National Health and Nutrition Examination Survey (NHANES 1) and the NHANES 1 Epidemiologic Follow-up Study (NHEFS) involving 4625 individuals followed, on average, for 18 years. The NHEFS involved 914 incident CHD cases and yielded an adjusted risk ratio of 1.09 (0.93-1.29) comparing individuals with neutrophil counts in the top third versus those in the bottom third of the population. In a meta-analysis involving the NHEFS and four other studies comprising a total of 1764 incident CHD cases, the association of CHD with neutrophil counts was somewhat stronger than those with other specific leucocyte components (combined risk ratio = 1.33 [1.17-1.50]) but there was substantial heterogeneity between the separate studies (chi(2) = 18.0, p < 0.001).Conclusions Although the present synthesis provides the most comprehensive assessment so far of specific leucocyte components in CHD, additional prospective data will be needed to resolve whether neutrophil. counts are much stronger predictors of CHD risk than other components. (C) 2004 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.