Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer.
Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer.
复制标题
卤烯醇吡喃酮和吗啉酮作为前列腺癌的抗肿瘤剂。
DOI：
10.1016/j.bmcl.2012.05.038
复制
发表时间：
2012
影响因子：
2.7
通讯作者：
Long,TimothyE
中科院分区：
文献类型：
--
作者：
Mock,JasonN;Taliaferro,JohnP;Lu,Xiao;Patel,SravanKumar;Cummings,BrianS;Long,TimothyE
Haloenol pyran-2-ones and morpholin-2-ones were synthesized and evaluated as inhibitors of cell growth in two different prostate human cancer cell lines (PC-3 and LNCaP). Analogs derived from l- and d-phenylglycine were found to be the most effective antagonists of LNCaP and PC-3 cell growth. Additional studies reveal that the inhibitors induced G2/M arrest and the (S)-enantiomer of the phenylglycine-based derivatives was a more potent inhibitor of cytosolic iPLA2β.
