Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number.
Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number.
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DOI：
10.12659/ajcr.894274
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发表时间：
2015-09-11
期刊：
影响因子：
--
通讯作者：
Kohri K
中科院分区：
文献类型：
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作者：
Okada A;Iida K;Hamakawa T;Umemoto Y;Yasui T;Kawai N;Tozawa K;Sasaki S;Hayashi Y;Kohri K
病人：女性，77岁最终诊断：肾和膀胱神经内分泌癌症状：右腰痛药物治疗：无临床操作：CT ·肾肿瘤穿刺活检·膀胱肿瘤经尿道切除术专长：泌尿外科罕见疾病泌尿器官的神经内分泌癌（NEC）偶尔观察到，尽管肾脏和口唇同时发展尚未报道。我们报告一例转移性NEC的肾脏和膀胱在一个77岁的妇女谁接受肾活检和经尿道切除膀胱肿瘤。病理学检查显示肾脏和膀胱样本中存在NEC。免疫组化检查显示突触素、嗜铬粒蛋白A和CD 56强阳性染色，细胞角蛋白AE 1/3和Cam 5.2局灶性阳性染色。荧光原位杂交证实肿瘤组织中3号染色体拷贝数增加，3q 21、5 q22 -23、10 q26和13 q14缺失。这是一例罕见的肾源性肿瘤NEC特异性遗传异常病例，也是首次发现肾源性NEC通过尿路转移至膀胱的报告。
Patient: Female, 77 Final Diagnosis: Neuroendocrine carcinoma of the kidney and bladder Symptoms: Right lumbar pain Medication: None Clinical Procedure: CT • needele biopsy of renal tumor • transyrethral resection of bladder tumor Specialty: Urology Rare disease Neuroendocrine carcinomas (NECs) of the urological organs are observed occasionally, although simultaneous development in the kidney and blabber has not been reported. We report a case of a metastatic NEC of the kidney and bladder in a 77-year-old woman who underwent renal biopsy and transurethral resection of the bladder tumor. Pathological examination revealed NEC in the kidney and the bladder samples. Immunohistochemical examination revealed strongly positive staining for synaptophysin, chromogranin A, and CD56, and focally positive staining for cytokeratin AE 1/3 and Cam 5.2. Fluorescence in situ hybridization confirmed the increased chromosome 3 copy number, and loss of hybridization in 3q21, 5q22–23, 10q26, and 13q14 was detected when the tumor samples were compared with normal samples. This is a rare case of NEC-specific genetic abnormalities in a kidney-derived tumor, and is the first report to identify kidney-derived NEC that metastasized to the bladder via the urinary tract.