No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families
No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families
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DOI：
10.1016/j.schres.2007.02.003
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发表时间：
2007-07-01
影响因子：
4.5
通讯作者：
Hwu, Hai-Gwo
中科院分区：
文献类型：
--
作者：
Liu, Chih-Min;Liu, Yu-Li;Hwu, Hai-Gwo
一些连锁研究表明，精神分裂症与染色体6p区域有显著的连锁关系，该区域包括位置候选基因Dystrobrevin-binding protein 1（DTNBP 1）。目的是在693个台湾家庭中检查候选基因的关联证据，其中至少有两个受影响的兄弟姐妹患有精神分裂症。我们对该基因的9个SNPs进行了基因分型，平均标记间距离为17 kb。用GOLD计算标记间连锁不平衡。用TRANSMIT程序进行单基因座和单倍型关联分析。我们发现精神分裂症和DTNBP 1之间没有显着的关联，无论是通过单基因座或单倍型分析。我们未能复制DTNBP 1和精神分裂症之间的关联证据，该基因可能不会在这个台湾家庭样本的精神分裂症的病因中发挥重要作用。(c)2007 Elsevier B. V.保留所有权利。
Several linkage studies have shown significant linkage of schizophrenia to chromosome 6p region, which includes the positional candidate genes, Dystrobrevin-binding protein 1 (DTNBP1). The aim was to examine the association evidence of the candidate gene in 693 Taiwanese families with at least two affected siblings of schizophrenia. We genotyped nine SNPs of this gene with average intermarker distance of 17 kb. Intermarker linkage disequilibrium was calculated with GOLD. Single locus and haplotype association analyses were performed with TRANSMIT program. We found no significant association between schizophrenia and DTNBP1 either through single locus or haplotype analyses. We failed to replicate the association evidence between DTNBP1 and schizophrenia and this gene may not play a major role in the etiology of schizophrenia in this Taiwanese family sample. (c) 2007 Elsevier B.V. All rights reserved.