New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease
New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease
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DOI：
10.1016/j.bcmd.2013.10.004
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发表时间：
2014-04-01
影响因子：
2.3
通讯作者：
Strouse, John J.
中科院分区：
文献类型：
--
作者：
Barodka, Viachaslau M.;Nagababu, Enika;Strouse, John J.
镰状细胞病（SCD）与氧化应激增加和不可逆的膜变化有关，这些变化源于脱氧血红蛋白S（HbS）的不稳定性和聚合。红细胞膜变化之间的关系进行了研究，通过减少变形性和氧化应激，增加血红素降解的评估。本文对27例SCD患者和7例镰状性状患者的红细胞变形能力和血红素降解进行了比较。变形能力和血红素降解的变化增加的顺序控制到性状非危机SCD危机SCD变形能力和血红素降解之间的一个非常显着的负相关。然而，定量分析这些不同群体的受试者的变形性和血红素降解的变化表明，镰刀性状对变形性的影响比血红素降解小得多，而危机影响变形性在更大程度上比血红素降解。这些发现提供了深入了解SCD进展过程中红细胞氧化应激和膜损伤的相对贡献，从而更好地理解SCD的病理生理学。爱思唯尔公司出版
Sickle cell disease (SCD) is associated with increase in oxidative stress and irreversible membrane changes that originates from the instability and polymerization of deoxygenated hemoglobin S (HbS). The relationship between erythrocyte membrane changes as assessed by a decrease in deformability and oxidative stress as assessed by an increase in heme degradation was investigated. The erythrocyte deformability and heme degradation for 27 subjects with SCD and 7 with sickle trait were compared with normal healthy adults. Changes in both deformability and heme degradation increased in the order of control to trait to non-crisis SCD to crisis SCD resulting in a very significantly negative correlation between deformability and heme degradation. However, a quantitative analysis of the changes in deformability and heme degradation for these different groups of subjects indicated that sickle trait had a much smaller effect on deformability than on heme degradation, while crisis affects deformability to a greater extent than heme degradation. These findings provide insights into the relative contributions of erythrocyte oxidative stress and membrane damage during the progression of SCD providing a better understanding of the pathophysiology of SCD. Published by Elsevier Inc.