CONCENTRATION GRADIENTS FOR HVA, 5-HIAA, ASCORBIC-ACID, AND URIC-ACID IN CEREBROSPINAL-FLUID
CONCENTRATION GRADIENTS FOR HVA, 5-HIAA, ASCORBIC-ACID, AND URIC-ACID IN CEREBROSPINAL-FLUID
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DOI：
10.1016/0006-3223(90)90470-m
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发表时间：
1990-04-15
影响因子：
10.6
通讯作者：
NAGY, E
中科院分区：
文献类型：
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作者：
DEGRELL, I;NAGY, E
测定精神和神经功能受损患者腰椎和池脑脊液（CSF）中HVA、5-HIAA、抗坏血酸和尿酸的浓度。池中HVA和5-HIAA的浓度分别是腰椎标本的6.1倍和2.7倍，池中尿酸水平是腰椎标本的一半，但抗坏血酸浓度无显著差异。腰池代谢物浓度与5-HIAA和抗坏血酸的相关性较高，与HVA和尿酸的相关性较低。池脑脊液中HVA-5-HIAA、5- hiaa -抗坏血酸和5- hiaa -尿酸水平有显著相关性。这些相关性在腰椎脑脊液中消失。这些发现表明，通过腰椎测量来推断池神经递质代谢物浓度对于HVA是不合理的，但对于5-HIAA则不是。
Concentrations of HVA, 5-HIAA, ascorbic acid, and uric acid in the lumbar and cisternal cerebrospinal fluid (CSF) were measured in psychiatric and neurologically impaired patients. The concentration of HVA is 6.1 times and of 5-HIAA 2.7 times higher in cisternal than in lumbar samples, the cisternal level of uric acid is half that of the lumbar region, but no significant differences were found in ascorbic acid concentrations. Correlation between lumbar and cisternal metabolite concentrations is high for 5-HIAA and ascorbic acid, and is less for HVA and uric acid. In cisternal CSF there is a significant correlation betwene levels of HVA-5-HIAA, 5-HIAA-ascorbic acid, and 5-HIAA-uric acid. These correlations disappear in lumbar CSF. These findings indicate that extrapolations to cisternal neurotransmitter metabolite concentration from lumbar measures are unwarranted for HVA, but not for 5-HIAA.