Assessing benefits and harms of hormone replacement therapy: clinical applications.

Assessing benefits and harms of hormone replacement therapy: clinical applications.
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评估激素替代疗法的益处和危害:临床应用。

DOI:
10.1001/jama.288.7.882
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发表时间:
2002
期刊:
JAMA
影响因子:
--
通讯作者:
H. Nelson
H. Nelson
中科院分区:
--
文献类型:
--
作者:
H. Nelson

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据估计,美国有三分之一的绝经后妇女使用激素替代疗法(HRT)来治疗绝经症状和预防慢性疾病。在这种广泛使用的背景下,越来越多的证据表明HRT的潜在危害,特别是长期使用。医生和患者经常对如何在个别病例中使用研究结果感到困惑。这篇文章适用于目前的证据状态的好处和危害HRT的管理决策在4个临床情况。患者的偏好以及证据对这些决定很重要。需要定期重新讨论益处和危害,以应用新发表的证据,并重新评估新出现的风险、合并症和个人需求。
An estimated one third of postmenopausal women in the United States use hormone replacement therapy (HRT) to treat symptoms of menopause and prevent chronic conditions. In the context of this widespread use, evidence has been growing about the potential harms of HRT, particularly regarding long-term use. Physicians and patients are often confused about how to use results of studies in individual cases. This article applies the current state of evidence for the benefits and harms of HRT to management decisions in 4 clinical situations. Patient preferences, as well as evidence, are important for these decisions. Benefits and harms need to be readdressed periodically to apply newly published evidence and to reassess emerging risks, comorbidities, and needs of individuals.
一项大型前瞻性研究中绝经后激素的使用和胆囊切除术。
DOI: --
发表时间: 1994
影响因子: 7.2
作者:
Grodstein,F;Colditz,GA;Stampfer,MJ
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雌激素替代治疗的时机以最佳预防骨质疏松症。
DOI: 10.1210/jcem.86.12.8079
发表时间: 2001
期刊: The Journal of clinical endocrinology and metabolism
影响因子: --
作者:
Cauley,JA;Zmuda,JM;Ensrud,KE;Bauer,DC;Ettinger,B;StudyofOsteoporoticFracturesResearchGroup
通讯作者: StudyofOsteoporoticFracturesResearchGroup
DOI: 10.1093/jnci/94.7.497
发表时间: 2002-04-03
影响因子: 10.3
作者:
Riman, T;Dickman, PW;Persson, IR
通讯作者: Persson, IR