At the Heart of Immune Checkpoint Inhibitor-Induced Immune Toxicity.
At the Heart of Immune Checkpoint Inhibitor-Induced Immune Toxicity.
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免疫检查点抑制剂引起的免疫毒性的核心。
DOI：
10.1158/2159-8290.cd-21-0091
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发表时间：
2021
期刊：
影响因子：
28.2
通讯作者：
Bluestone,JeffreyA
中科院分区：
文献类型：
--
作者：
Young,Arabella;Bluestone,JeffreyA
wei及其同事展示了一种免疫介导的心肌炎小鼠遗传模型，该模型与癌症患者免疫检查点抑制剂（CPI）诱导的心肌炎具有同源性。他们证明abataccept （CTLA4-Ig）在小鼠模型中限制心脏毒性，因此可能改善cpi诱导的癌症患者心肌炎，同时潜在地保持抗肿瘤活性。参见Wei等人的相关文章，第614页。
SummaryWei and colleagues showcase a genetic mouse model of immune-mediated myocarditis that shares homology with immune checkpoint inhibitor (CPI)–induced myocarditis in patients with cancer. They demonstrate that abatacept (CTLA4–Ig) limits cardiac toxicity in the mouse model and, thus, may ameliorate the CPI-induced myocarditis in patients with cancer while potentially maintaining antitumor activity.See related article by Wei et al., p. 614.