Interleukin-7 - An interleukin for rejuvenating the immune system
Interleukin-7 - An interleukin for rejuvenating the immune system
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DOI：
10.1196/annals.1297.021
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Ngom, PT
中科院分区：
文献类型：
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作者：
Aspinall, R;Henson, S;Ngom, PT
个体（20-30岁）感染病毒将引起T（胸腺衍生）淋巴细胞的反应，其中约有3 × 10（11）。如果个体之前未接触过病毒，则应答将来自幼稚T细胞亚群（该年龄时占总T细胞池的50 +/- 10%），其中包含胸腺产生的近期胸腺移行物，约每天10（8）个。它们的抗原特异性受体具有由其两条链（α和β）的构象控制的确定的特异性，并且特异性的库在2 × 10（7）至10（8）的区域中的某处。成功的应答导致克隆扩增和对感染剂的记忆T细胞的产生。
Infection of an individual (aged 20-30 years) by a virus will cause a response from the T (thymus derived) lymphocytes of which there are approximately 3 x 10(11). If the individual has not met the virus before, the response will come from the naive T cell subset (50 +/- 10% of the total T cell pool at this age) containing recent thymic emigrants produced from the thymus at approximately 10(8) per day. Their antigen-specific receptor has a defined specificity governed by the conformation of its two chains (alpha and beta), and the repertoire of specificities is somewhere in the region of 2 x 10(7) to 10(8). A successful response leads to clonal expansion and the generation of memory T cells to the infecting agent.