Inter-scanner differences in in vivo QCT measurements of the density and strength of the proximal femur remain after correction with anthropomorphic standardization phantoms
Inter-scanner differences in in vivo QCT measurements of the density and strength of the proximal femur remain after correction with anthropomorphic standardization phantoms
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DOI：
10.1016/j.medengphy.2014.06.010
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发表时间：
2014-10-01
影响因子：
2.2
通讯作者：
Lang, Thomas F.
中科院分区：
文献类型：
--
作者：
Carpenter, R. Dana;Saeed, Isra;Lang, Thomas F.
在使用两种或多种不同定量计算机断层扫描（QCT）成像系统的多中心研究和纵向研究中，拟人标准化体模（ASP）用于校正扫描仪间差异并允许合并数据。在这项研究中，20名女性在两种成像系统上进行体内成像，以评估髋关节积分BMD（iBMD）、骨小梁BMD（tBMD）、皮质BMD（cBMD）、股骨颈屈服力矩（M-y）和屈服力（F-y）以及站立（FEstance）和跌倒（FEfall）载荷下股骨有限元推导强度的扫描仪间差异。使用六种不同的ASP来推导扫描仪间校正方程。除M-y和FEfall外，在所有测量中均检测到显著（p < 0.05）扫描仪间差异，并且没有基于ASP的校正能够将扫描仪间变异性降低到相应的扫描仪内精度水平。即使在扫描仪间平均差异无统计学意义的情况下，扫描仪间变异性也远高于扫描仪内精密度。检测到身体大小对BMD扫描仪间差异的显著影响（p < 0.01），表明需要解决身体大小对QCT测量的影响。本研究的结果表明，即使使用ASP，基于QCT的BMD和骨强度测量的扫描仪间差异仍显着。(C)2014年IPEM。由爱思唯尔有限公司出版。保留所有权利。
In multicenter studies and longitudinal studies that use two or more different quantitative computed tomography (QCT) imaging systems, anthropomorphic standardization phantoms (ASPs) are used to correct inter-scanner differences and allow pooling of data. In this study, in vivo imaging of 20 women on two imaging systems was used to evaluate inter-scanner differences in hip integral BMD (iBMD), trabecular BMD (tBMD), cortical BMD (cBMD), femoral neck yield moment (M-y) and yield force (F-y), and finite-element derived strength of the femur under stance (FEstance) and fall (FEfall) loading. Six different ASPs were used to derive inter-scanner correction equations. Significant (p < 0.05) inter-scanner differences were detected in all measurements except M-y and FEfall, and no ASP-based correction was able to reduce inter-scanner variability to corresponding levels of intra-scanner precision. Inter-scanner variability was considerably higher than intra-scanner precision, even in cases where the mean inter-scanner difference was statistically insignificant. A significant (p < 0.01) effect of body size on inter-scanner differences in BMD was detected, demonstrating a need to address the effects of body size on QCT measurements. The results of this study show that significant inter-scanner differences in QCT-based measurements of BMD and bone strength can remain even when using an ASP. (C) 2014 IPEM. Published by Elsevier Ltd. All rights reserved.