Feeding associated neonatal necrotizing enterocolitis (Primary NEC) is an inflammatory bowel disease.
Feeding associated neonatal necrotizing enterocolitis (Primary NEC) is an inflammatory bowel disease.
复制标题
DOI：
10.1016/j.pathophys.2013.11.006
复制
发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Munshi UK
中科院分区：
文献类型：
--
作者：
Clark DA;Munshi UK
喂养早产儿后发生的新生儿坏死性小肠结肠炎的特点是严重的肠道炎症和严重的全身代谢性酸中毒。结肠菌群发酵未消化的膳食碳水化合物，产生气体（CO2 和 H2）和短链有机酸。这些有机酸可以破坏肠粘膜并引发主要由常驻肥大细胞和从血液中招募的粒细胞驱动的炎症。全身性酸中毒是由肠酸引起的，而不是由无氧代谢产生的经典乳酸性酸中毒。全身性酸中毒进一步损害发炎的肠道，导致肠坏死。
Neonatal necrotizing enterocolitis which develops after feeding preterm infants is characterized by severe intestinal inflammation and profound systemic metabolic acidosis. The fermentation of undigested dietary carbohydrate by colonic flora yields gases (CO2 and H2) and short chain organic acids. These organic acids can disrupt the intestinal mucosa and initiate inflammation driven predominantly by resident mast cells and by granulocytes which are recruited from blood. A systemic acidosis ensues derived from intestinal acids, not classic lactic acidosis produced from anaerobic metabolism. The systemic acidosis further compromises inflamed bowel leading to bowel necrosis.