The functional anatomy of auditory hallucinations in schizophrenia
The functional anatomy of auditory hallucinations in schizophrenia
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DOI：
10.1016/s0925-4927(00)00068-8
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发表时间：
2000-11-20
影响因子：
2.3
通讯作者：
Jones, PB
中科院分区：
文献类型：
--
作者：
Lennox, BR;Park, SBG;Jones, PB
我们使用带有 3-T 磁体的连续全脑功能磁共振成像 (fMRI) 来绘制四名精神分裂症患者与幻听相关的大脑活动图。受试者在扫描仪中经历了幻觉发作，因此可以将同一个人的幻觉时期与休息时期进行比较。组分析表明，左右颞上回、左顶下皮质和左额中回有共同的激活区域。当对个体数据进行检查时，所有四名受试者的颞叶皮层和前额叶皮层区域在幻觉发作期间都被激活。这些发现支持幻听反映正常听觉通路异常激活的理论。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
We used continuous whole brain functional magnetic resonance imaging (fMRI) with a 3-T magnet to map the cerebral activation associated with auditory hallucinations in four subjects with schizophrenia. The subjects experienced episodes of hallucination whilst in the scanner so that periods of hallucination could be compared with periods of rest in the same individuals. Group analysis demonstrated shared areas of activation in right and left superior temporal gyri, left inferior parietal cortex and left middle frontal gyrus. When the data were examined on an individual basis, the temporal cortex and prefrontal cortex areas were activated during episodes of hallucination in all four subjects. These findings support the theory that auditory hallucination reflects abnormal activation of normal auditory pathways. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.