Association between offspring birth weight and atherosclerosis in middle aged men and women: British Regional Heart Study
Association between offspring birth weight and atherosclerosis in middle aged men and women: British Regional Heart Study
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DOI：
10.1136/jech.57.6.462
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发表时间：
2003-06-01
影响因子：
6.3
通讯作者：
Ebrahim, S
中科院分区：
文献类型：
--
作者：
Lawlor, DA;Smith, GD;Ebrahim, S
方法和数据来自英国区域心脏研究的Dewsbury和麦德斯通队列。对年龄在56-75岁的375名女性和425名男性进行了颈动脉B型超声测量，并进行了详细的体格检查、血液检查和研究护士访谈。所有测量的全部细节先前已报告。5在没有动脉粥样硬化斑块的情况下，在球起点测量颈动脉内膜中层厚度，球起点定义为动脉壁分叉形成球的点。在存在斑块的情况下，测量斑块的最大厚度，并将其作为内膜中层厚度。该测量提供了临床前动脉粥样硬化的指示。5对于有子女的参与者，要求提供其第一个子女的出生体重和性别的详细信息。采用多元线性回归评估后代出生体重与内膜中层厚度之间的相关性，并对潜在的混杂因素进行调整。内膜中层厚度测量值呈偏态分布，但记录值呈正态分布;记录值用于线性回归模型。
METHODS AND RESULTSData were used from the Dewsbury and Maidstone cohort of the British Regional Heart Study. B-mode ultrasound measurements of carotid arteries, together with a detailed physical examination, blood tests, and research nurse interview were undertaken on 375 women and 425 men, aged 56–75 years. Full details of all measurements have been reported previously. 5 In the absence of atherosclerotic plaque carotid intima media thickness was measured at the bulb origin, which was defined as the point at which the arterial wall diverges to form the bulb. In the presence of plaque, the maximum thickness of the plaque was measured and this was taken as the intima media thickness. This measure provides an indication of pre-clinical atherosclerosis. 5 For participants with children details of the birth weight and sex of their first offspring were requested. Multiple linear regression was used to assess the association between offspring birth weight and intima media thickness, with adjustment for potential confounding factors. Intima media thickness measurements had a skewed distribution but logged values were normally distributed; logged values were used in the linear regression models.