Uric Acid Best Predicts Metabolically Unhealthy Obesity With Increased Cardiovascular Risk in Youth and Adults
Uric Acid Best Predicts Metabolically Unhealthy Obesity With Increased Cardiovascular Risk in Youth and Adults
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DOI：
10.1002/oby.20061
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发表时间：
2013-01-01
期刊：
影响因子：
6.9
通讯作者：
Weghuber, Daniel
中科院分区：
文献类型：
--
作者：
Mangge, Harald;Zelzer, Sieglinde;Weghuber, Daniel
目的：肥胖患病率在世界范围内不断增长，主要负责心血管疾病，在西方世界最常见的死亡原因。本研究的基本原理是通过广泛的人体测量、实验室和超声血管评估，将代谢健康的、不健康的超重/肥胖的年轻和成年患者与健康的正常体重、年龄匹配的对照进行区分。设计与方法：对STYJOBS/EDECTA （STYrian青少年肥胖研究/动脉粥样硬化早期检测）队列的355名年轻人[8 - 18-60岁，175名（低/高），179名（低/高）]进行分析。STYJOBS/EDECTA （NCT00482924）是一项横断面研究，旨在调查除代谢综合征（MetS）外无疾病的正常和低/ob人群的代谢/心血管风险概况。结果：299名年轻ow/ob受试者（8-18-60岁）中，79人（45%）有met阳性标准。在这两个年龄组中，met的患病率在男性中更高。超重/肥胖受试者被分为“健康”（没有MetS标准，除非满足人体测量）和“不健康”（MetS阳性）。虽然身体脂肪百分比在“健康”组和“不健康”组之间没有差异，但“不健康”组的颈动脉内膜和内脏脂肪显著增加，颈动脉内膜中膜厚度（IMT）也显著增加。以MetS为因变量，进行了包括18岁青少年在内的两次逻辑回归。除年龄和性别外，通过t检验比较选择的潜在预测变量包括IMT、超敏c反应蛋白（US-CRP）、IL-6、丙二醛（MDA）、氧化LDL、瘦素、脂联素、尿酸（UA）、醛固酮、皮质醇、转氨酶、纤维蛋白原。在两组中，尿酸和瘦素和脂联素被证明是最好的预测因子。结论：血清UA水平是青少年和成人不健康肥胖的重要预测因子。
Objective: The obesity prevalence is growing worldwide and largely responsible for cardiovascular disease, the most common cause of death in the western world. The rationale of this study was to distinguish metabolically healthy from unhealthy overweight/obese young and adult patients as compared to healthy normal weight age matched controls by an extensive anthropometric, laboratory, and sonographic vascular assessment.Design and Methods: Three hundred fifty five young [8 to 18-60 years, 175 (ow/ob), 179 nw)] participants of the STYJOBS/EDECTA (STYrian Juvenile Obesity Study/Early DEteCTion of Atherosclerosis) cohort were analyzed. STYJOBS/EDECTA (NCT00482924) is a crossectional study to investigate metabolic/cardiovascular risk profiles in normal and ow/ob people free of disease except metabolic syndrome (MetS).Results: From 299 young ow/ob subjects (8-18-60 years), 79 (45%) had positive criteria for MetS. In both age groups, prevalence of MetS was greater among males. Overweight/obese subjects were divided into "healthy" (no MetS criterion except anthropometry fulfilled) and "unhealthy" (MetS positive). Although percentage body fat did not differ between "healthy" and "unhealthy" ow/ob, nuchal and visceral fat were significantly greater in the "unhealthy" group which had also significantly higher values of carotid intima media thickness (IMT). With MetS as the dependent variable, two logistic regressions including juveniles 18 years were performed. The potential predictor variables selected with the exception of age and gender by t test comparisons included IMT, ultrasensitive c-reactive protein (US-CRP), IL-6, malondialdehyde (MDA), oxidized LDL, leptin, adiponectin, uric acid (UA), aldosterone, cortisol, transaminases, fibrinogen. In both groups, uric acid and in adults only, leptin and adiponectin, turned out as the best predictor.Conclusion: Serum levels of UA are a significant predictor of unhealthy obesity in juveniles and adults.