Increased serum levels of CCL3, CXCL8, CXCL9, and CXCL10 in rosacea patients and their correlation with disease severity
Increased serum levels of CCL3, CXCL8, CXCL9, and CXCL10 in rosacea patients and their correlation with disease severity
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DOI：
10.1111/1346-8138.16329
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发表时间：
2022-03-01
影响因子：
3.1
通讯作者：
Zhao, Zhixiang
中科院分区：
文献类型：
--
作者：
Liu, Tangxiele;Li, Ji;Zhao, Zhixiang
酒渣鼻是一种常见的慢性炎症性皮肤病，涉及全球数百万患者。先前的研究已经强调了在酒渣鼻患者和酒渣鼻样小鼠模型的皮肤病变中多种趋化因子的上调。然而，这些趋化因子的血清水平及其临床意义尚未探讨。在这项研究中，我们的目的是检查一系列的趋化因子（包括CCL 2，CCL 3，CCL 20，CXCL 1，CXCL 8，CXCL 9，CXCL 10和CXCL 12）参与酒渣鼻的血清水平及其与疾病严重程度的相关性。使用Bio-RPPro人趋化因子测定来测量这些趋化因子的血清水平。研究者总体评估（伊加）用于评估红斑痤疮患者的丘疹/脓疱，而持续性红斑通过临床医生红斑评估（CEA）进行评估。我们的研究结果显示，与健康对照组相比，酒渣鼻患者血清中CCL 3、CXCL 8、CXCL 9和CXCL 10的浓度显著升高。其中，CCL 3、CXCL 8、CXCL 9与伊加评分呈正相关，CXCL 9、CXCL 10与CEA评分呈正相关。此外，在酒渣鼻样小鼠模型皮损中，相应受体CCL 3（Ccr 1）、CXCL 8（Cxcr 1和Cxcr 2）、CXCL 9和CXCL 10（Cxcr 3）的表达均显著增加，其中CXCR 2和CXCR 3在酒渣鼻患者皮肤中高表达。我们的研究结果表明，CCL 3，CXCL 8，CXCL 9和CXCL 10可能作为酒渣鼻的血清指标，可以帮助疾病的严重程度评估。这项研究的发现也可能有助于未来开发新的红斑痤疮靶向治疗方法。(c)2022日本皮肤病学会
Rosacea is a common chronic inflammatory skin disease involving millions of patients worldwide. Previous studies have highlighted the upregulation of a variety of chemokines in the skin lesions of both rosacea patient and rosacea-like mouse model. However, the serum levels of these chemokines and their clinical significance have not been explored before. In this study, we aimed at examining the serum levels of a series of chemokines (including CCL2, CCL3, CCL20, CXCL1, CXCL8, CXCL9, CXCL10, and CXCL12) implicated in rosacea and their correlation with disease severity. Bio-Plex Pro Human Chemokine Assays were used to measure the serum levels of these chemokines. Investigator's Global Assessment (IGA) was applied for assessing the papules/pustules of rosacea patients, while persistent erythema was evaluated by the Clinician's Erythema Assessment (CEA). Our results revealed that the serum concentration of CCL3, CXCL8, CXCL9, and CXCL10 were markedly elevated in rosacea patients compared to healthy controls. Among them, the levels of CCL3, CXCL8, and CXCL9 were positively correlated with the IGA score, while serum CXCL9 and CXCL10 were positively related with the CEA score of rosacea patients. What's more, the expression of the corresponding receptors of CCL3 (Ccr1), CXCL8 (Cxcr1 and Cxcr2), CXCL9, and CXCL10 (Cxcr3) were all significantly increased in the skin lesions of rosacea-like mouse model with CXCR2 and CXCR3 highly expressed in rosacea patient skins. Our results indicated that CCL3, CXCL8, CXCL9, and CXCL10 might potentially serve as serum indicators for rosacea and could assist the severity evaluation of disease. Findings in this study would also potentially help to develop new targeted therapies for rosacea in future. (c) 2022 Japanese Dermatological Association