In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms.
In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms.
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DOI：
10.1016/j.neuroscience.2016.01.072
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发表时间：
2016-04-21
期刊：
影响因子：
3.3
通讯作者：
Gorman MR
中科院分区：
文献类型：
--
作者：
Evans JA;Gorman MR
视交叉上核 (SCN) 是一个神经振荡器网络，负责调节哺乳动物行为和生理的日常节律。在过去的十年里，人们对 SCN 时钟神经元如何在时间和空间上协调在一起形成一个有凝聚力的群体有了很多了解。尽管有这一见解，但关于 SCN 神经元如何相互通信以产生网络的新兴特性仍然未知。在这里，我们回顾了当前对 SCN 时钟细胞之间通信的理解，并重点介绍了一系列正式测定，其中 SCN 相互作用的变化为行为中的昼夜节律波形提供了可塑性。未来的研究将分析行为分析与现代神经科学技术相结合，有可能对 SCN 回路机制提供更深入的了解。
The suprachiasmatic nucleus (SCN) is a network of neural oscillators that program daily rhythms in mammalian behavior and physiology. Over the last decade much has been learned about how SCN clock neurons coordinate together in time and space to form a cohesive population. Despite this insight, much remains unknown about how SCN neurons communicate with one another to produce emergent properties of the network. Here we review the current understanding of communication among SCN clock cells and highlight a collection of formal assays where changes in SCN interactions provide for plasticity in the waveform of circadian rhythms in behavior. Future studies that pair analytical behavioral assays with modern neuroscience techniques have the potential to provide deeper insight into SCN circuit mechanisms.