ALLELIC INACTIVATION REGULATES OLFACTORY RECEPTOR GENE-EXPRESSION
ALLELIC INACTIVATION REGULATES OLFACTORY RECEPTOR GENE-EXPRESSION
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DOI：
10.1016/s0092-8674(94)90562-2
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发表时间：
1994-09-09
期刊：
影响因子：
64.5
通讯作者：
AXEL, R
中科院分区：
文献类型：
--
作者：
CHESS, A;SIMON, I;AXEL, R
我们提出了一个模型，其中对气味受体基因家族施加控制层次，以确保感觉神经元表达来自 1000 个基因家族的单个受体。我们提出顺式调控元件指导大量连锁受体基因中仅一个基因的随机表达。此外，在单个神经元中只有一个编码多个受体基因的等位基因阵列是活跃的。我们证明，在表达给定受体的神经元中，表达仅源自一个等位基因。此外，我们观察到编码气味受体的等位基因是异步复制的，这种现象始终与等位基因失活相关。该模型涉及一个等位基因阵列的失活和活性阵列的顺式控制，提供了一种使单个神经元表达一个或少量受体的机制。
We suggest a model in which a hierarchy of controls is exerted on the family of odorant receptor genes to assure that a sensory neuron expresses a single receptor from a family of 1000 genes. We propose that a cis-regulatory element directs the stochastic expression of only one gene from a large array of linked receptor genes. Moreover, only one allelic array encoding multiple receptor genes is active in an individual neuron. We demonstrate that in a neuron expressing a given receptor, expression derives exclusively from one allele. In addition, we observe that alleles encoding the odorant receptors are replicated asynchronously, a phenomenon consistently associated with allelic inactivation. This model, involving inactivation of one allelic array and cis control of the active array, provides a mechanism such that individual neurons express one or a small number of receptors.