Total cholesterol and lipoprotein composition are associated with dry eye disease in Korean women.
Total cholesterol and lipoprotein composition are associated with dry eye disease in Korean women.
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DOI：
10.1186/1476-511x-12-84
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发表时间：
2013-06-05
影响因子：
4.5
通讯作者：
Na KS
中科院分区：
文献类型：
--
作者：
Chun YH;Kim HR;Han K;Park YG;Song HJ;Na KS
本研究旨在确定韩国人群中血脂异常与干眼症（DED）之间的关系。这项基于人群的研究招募了5，627名成年人（年龄>19岁），他们参加了2010年至2011年第五次年度韩国国家健康和营养检查调查的第一年。对临床诊断为DED的患者进行问卷调查，并收集血液生化分析数据。血脂异常定义为以下任何一种：高胆固醇血症（总胆固醇> 200 mg/dL）、高甘油三酯血症（甘油三酯> 150 mg/dL）、低水平的高密度脂蛋白（<40 mg/dL）或高水平的低密度脂蛋白（>100 mg/dL）。在调整人口统计学（年龄和体重指数），生活方式（吸烟，饮酒，运动和居住区）和医学因素（糖尿病，高血压，既往眼科手术，绝经和风湿性疾病）后，发现血清胆固醇水平升高与女性DED的可能性增加相关（比值比，1.77; 95%置信区间，1.127-2.78）。DED在韩国人群中被发现与高血清胆固醇水平有关。这项研究的结果强调了眼部检查和独立的血脂监测在血脂异常患者中的重要性，因为它可能与DED进展相关。
This study aimed to determine the relationship between dyslipidemia and dry eye disease (DED) in a Korean population. This population-based study enrolled 5,627 adults (aged >19 years) who were participating in the first year of the fifth annual Korea National Health and Nutrition Examination Survey from 2010 to 2011. Clinically diagnosed DED and its symptoms were surveyed, and biochemical blood analysis data were collected. Dyslipidemia was defined as any of the following: hypercholesterolemia (total cholesterol > 200 mg/dL), hypertriglyceridemia (triglyceride > 150 mg/dL), low levels of high-density lipoprotein (<40 mg/dL), or high levels of low-density lipoprotein (>100 mg/dL). After adjusting for demographics (age and body mass index), lifestyle (smoking, drinking, exercise, and residential district), and medical factors (diabetes, hypertension, previous ophthalmic surgery, menopause, and rheumatologic disease), elevated serum cholesterol level was found to be associated with increased likelihood of DED (odds ratio, 1.77; 95% confidence interval, 1.127–2.78) in women. DED in a Korean population was found to be associated with high serum cholesterol levelsThe results of this study highlight the significance of eye examinations and independent lipid profile monitoring in patients with dyslipidemia because of its possible correlation with DED progression.