Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer.
Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer.
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DOI：
10.3892/ijo.31.2.333
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发表时间：
2007-08
影响因子：
5.2
通讯作者：
Y. Kosaka;K. Mimori;F. Tanaka;H. Inoue;M. Watanabe;M. Mori
中科院分区：
文献类型：
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作者：
Y. Kosaka;K. Mimori;F. Tanaka;H. Inoue;M. Watanabe;M. Mori
人Mob作为肿瘤抑制因子1（MATS 1）已被证明通过调节细胞增殖和凋亡在肿瘤生长中起关键作用。我们评估了MATS 1在结直肠癌患者中的表达并评估了其临床病理意义。采用实时荧光定量RT-PCR方法检测了72例结直肠癌组织中MATS 1 mRNA的表达。免疫组化法检测MATS 1蛋白表达。MATS 1 mRNA在大肠癌组织中的表达明显低于正常大肠组织（p<0.05）。MATS 1低表达组的肿瘤体积大、浸润深、淋巴管浸润、肝转移等临床病理特征明显高于对照组（p<0.05）。低表达组预后差于高表达组。与相应的非癌结肠上皮细胞相比，肿瘤细胞中的MATS 1蛋白表达减少。肿瘤组织中MATS 1 mRNA表达受到抑制，其低表达与肿瘤的生长、侵袭和转移有关。具体而言，低MATS 1表达可能是肝转移的良好标志物，肝转移是结直肠癌患者的危及生命的指标。
Human Mob as tumor suppressor 1 (MATS1) has been shown to play a crucial role in tumor growth by regulating cell proliferation and apoptosis. We evaluated the expression of MATS1 in colorectal cancer patients and assessed its clinicopathological significance. MATS1 mRNA expression in paired tumor/normal samples from 72 cases of colorectal cancer was evaluated, using real-time RT-PCR analysis. MATS1 protein expression was determined by immunohistochemical staining. MATS1 mRNA expression was significantly lower in tumor tissues than in normal colorectal tissues (p<0.05). Clinicopathologically, factors such as incidence of large tumor size, deep invasion, lymphatic permeation and liver metastasis were significantly more frequent in the low MATS1 expression group (p<0.05). Prognosis of the low expression group tended to be poorer than that of the high expression group. MATS1 protein expression was diminished in tumor cells compared with corresponding non-cancer colon epithelial cells. MATS1 mRNA expression is suppressed in tumor tissue and its low expression is associated with tumor growth, invasion and metastasis of colorectal cancer. Specifically, low MATS1 expression may be a good marker of liver metastasis, a life-threatening indicator for colorectal cancer patients.