PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.
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DOI：
10.2217/14622416.9.11.1695
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发表时间：
2008-11
期刊：
影响因子：
2.1
通讯作者：
Krasowski MD
中科院分区：
文献类型：
--
作者：
Zhang B;Xie W;Krasowski MD
PXR受体（NR 1 I2）是核受体超家族的成员，调节药物代谢酶和转运蛋白的表达，这些酶和转运蛋白参与哺乳动物对其化学环境的反应。相同的酶和转运系统也参与许多内源性化学物质的体内平衡。PXR的调节功能涉及正常生理和疾病，例如药物-药物相互作用、肝脂肪变性、维生素D稳态、胆汁酸稳态、类固醇激素稳态和炎性肠病。因此，该受体的任何遗传变异都可能对外源性物质和内生物质的处置产生广泛影响。了解PXR基因多态性有助于了解人类药物反应的变化，确保安全用药。PXR基因多态性与几种疾病的相关性也表明，这种受体可能是一种有效的治疗肝肠道疾病，如炎症性肠病和原发性硬化性胆管炎。
The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of drug-metabolic enzymes and transporters involved in the responses of mammals to their chemical environment. The same enzyme and transporter systems are also involved in the homeostasis of numerous endogenous chemicals. The regulatory function of PXR is implicated in normal physiology and diseases, such as drug–drug interactions, hepatic steatosis, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory bowel diseases. As such, any genetic variations of this receptor could potentially have widespread effects on the disposition of xenobiotics and endobiotics. Knowledge concerning the genetic polymorphisms of PXR may help to understand the variations in human drug response and ensure safe drug use. The correlation of PXR genetic polymorphisms with several disease conditions also suggests that this receptor may represent a valid therapeutic for hepato-intestinal disorders such as inflammatory bowel disease and primary sclerosing cholangitis.
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DOI：
10.1073/pnas.95.21.12208
发表时间：
1998-10-13
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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影响因子：
3.4
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影响因子：
3.6
作者：
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