Dementia with Lewy bodies from the perspective of tauopathy
Dementia with Lewy bodies from the perspective of tauopathy
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DOI：
10.1007/s00401-002-0644-3
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发表时间：
2003-03-01
影响因子：
12.7
通讯作者：
Kosaka, K
中科院分区：
文献类型：
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作者：
Iseki, E;Togo, T;Kosaka, K
我们通过免疫组织化学方法研究了 46 例路易体痴呆 (DLB) 病例中神经元和神经胶质细胞中磷酸化 tau 蛋白积累的患病率和模式。所有46例患者的海马区均发现由神经原纤维缠结（NFT）和前缠结神经元组成的tau阳性神经元，尽管在低NFT阶段的病例中，tau阳性神经元中前缠结神经元的比例较高。 46例中有18例在脑室周围区域发现Tau阳性星形胶质细胞，部分表现为嗜银刺状星形胶质细胞。相比之下，46 例中有 9 例在皮质下白质中发现了 tau 阳性少突胶质细胞，代表嗜银卷曲体。在与卷曲体相同的病例中，在海马区也发现了 tau 阳性嗜银颗粒。 9例tau阳性卷曲体和颗粒包含在18例tau阳性星形胶质细胞中，并且在低NFT阶段的比例比46例tau阳性神经元的比例更大。 Tau 阳性神经元对抗三重复 (3R) 和 -4R tau 特异性抗体均呈阳性，而 tau 阳性星形胶质细胞、卷曲体和颗粒主要对抗 4R tau 特异性抗体呈阳性。这些 tau 阳性结构对抗 α-突触核蛋白抗体呈阴性。这些发现表明，DLB 中的 tau 积累代表了具有所有六种 tau 异构体的 tau 阳性神经元和具有 4R tau 异构体的 tau 阳性星形胶质细胞、卷曲体和颗粒，并且不同的细胞骨架异常在包括 DLB 在内的一些神经退行性痴呆疾病之间形成了联系。
We immunohistochemically investigated the prevalence and pattern of phosphorylated tau accumulation in neurons and glia in 46 cases of dementia with Lewy bodies (DLB). Tau-positive neurons composed of neurofibrillary tangles (NFT) and pretangle neurons were found in the hippocampal area in all 46 cases, although the ratio of pretangle neurons in tau-positive neurons was higher in the cases showing low NFT stages. Tau-positive astrocytes were found in the periventricular area in 18 of 46 cases, and partly represented argyrophilic thorn-shaped astrocytes. In contrast, tau-positive oligodendroglia were found in the subcortical white matter in 9 of 46 cases, and represented argyrophilic coiled bodies. Tau-positive argyrophilic grains were found in the hippocampal area in the same cases as those with coiled bodies. The 9 cases with tau-positive coiled bodies and grains were included in the 18 cases with tau-positive astrocytes, and showed larger proportions in the low NFT stages than the 46 cases with tau-positive neurons. Tau-positive neurons were positive both to anti-three-repeat (3R) and -4R tau-specific antibodies, while tau-positive astrocytes, coiled bodies and grains were predominantly positive to anti-4R tau-specific antibody. These tau-positive structures were negative to anti-a-synuclein antibody. These findings suggest that the tau accumulation in DLB represents both tau-positive neurons with all six tau isoforms and tau-positive astrocytes, coiled bodies and grains with the 4R tau isoform, and that the different cytoskeletal abnormalities form a link between some neurodegenerative dementing disorders including DLB.