The mother rat's vomeronasal organ is involved in detection of dodecyl propionate, the pup's preputial gland pheromone
The mother rat's vomeronasal organ is involved in detection of dodecyl propionate, the pup's preputial gland pheromone
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DOI：
10.1016/s0031-9384(98)00334-5
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发表时间：
1999-05-01
影响因子：
2.9
通讯作者：
Vernet-Maury, E
中科院分区：
文献类型：
--
作者：
Brouette-Lahlou, I;Godinot, F;Vernet-Maury, E
本研究的目的是分析主要和辅助嗅觉系统在 Wistar 大鼠母性行为的特定模式中各自的作用：特定舔幼崽的肛门生殖器区域，这是一种对幼崽生存至关重要的行为模式 - 不舔的幼崽无法排便，并死亡。丙酸十二烷基酯 (DP) 是一种来自幼鼠包皮腺的化学剂，被发现可以指导和调节幼鼠的肛门生殖器舔舐行为。初产母鼠接受以下治疗之一：手术切除犁鼻器（以下简称 VNX），用 5% ZnSO4 溶液（ZN）冲洗鼻腔，这两种治疗（VNX + ZN），手术对照（SC），盐水冲洗对照（SA），这两种治疗（SC + SA）和正常对照（N）。与对照组或因鼻腔硫酸锌冲洗导致嗅觉丧失的雌性相比，VNX 雌性小鼠中存活到 15 天的幼仔数量较少（仅 75%）（>95% 的存活率）。此外，VNX 和/或 ZN 治疗会损害幼仔的生长（质量随时间增加）。 VNX 雌性在舔幼崽的肛门生殖器区域上花费的时间比正常情况下多，尽管这些该死的雌性没有像正常雌性那样花那么多时间与幼崽的头或涂有十二烷基丙酸酯的滤纸密切接触。本文报道的实验表明，犁鼻器中的化学感应受体介导 MAGL 对幼犬信息素丙酸十二酯（一种来自幼犬包皮腺分泌的信息素）的 MAGL 反应，维持幼犬对肛门生殖器的舔舐。 (C) 1999 爱思唯尔科学公司。
The aim of the present study was to analyze the respective roles of main and accessory olfactory systems in a particular pattern of Wistar rat maternal behavior: specific licking of pup's anogenital areas, a behavioral pattern crucial to pup survival-nonlicked pups cannot defecate, and die. Dodecyl propionate (DP), a chemical agent from rat pup's preputial glands was found to direct and regulate pup's anogenital licking. Primiparous dams underwent one of the following treatments: surgical removal of the vomeronasal organ (hereafter VNX), irrigation of nasal cavities with 5% ZnSO4 solution (ZN), both these treatments (VNX + ZN), surgical control (SC), saline irrigation control (SA), both these treatments (SC + SA), and normal control (N). Fewer pups (only 75%) of VNX dams survived to 15 days of age compared to controls or to females rendered anosmic by zinc-sulfate irrigation of the nasal cavity (>95% survival). Furthermore, pup growth (mass increase over time) was impaired by VNX and/or ZN treatment. Greater than normal amounts of time were spent licking pups' anogenital area by VNX females, although these darns did not spend as much time as normal females in close contact with either pups heads or filter papers anointed with dodecyl propionate. The experiments reported herein suggest that the chemosensory receptors in the vomeronasal organ of darns mediate MAGL responses to pup pheromone, dodecyl propionate, a pheromone from pups' preputial glands secretion, sustaining pups' anogenital licking by darns. (C) 1999 Elsevier Science Inc.