Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation.

Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation.
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DOI:
10.1038/bmt.2012.5
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发表时间:
2012-03
影响因子:
4.8
通讯作者:
Sociedade Brasileira de Transplante de Medula Ossea
Sociedade Brasileira de Transplante de Medula Ossea
中科院分区:
医学3区
文献类型:
--
作者:
Majhail NS;Rizzo JD;Lee SJ;Aljurf M;Atsuta Y;Bonfim C;Burns LJ;Chaudhri N;Davies S;Okamoto S;Seber A;Socie G;Szer J;Van Lint MT;Wingard JR;Tichelli A;Center for International Blood and Marrow Transplant Research;American Society for Blood and Marrow Transplantation;European Group for Blood and Marrow Transplantation;Asia-Pacific Blood and Marrow Transplantation Group;Bone Marrow Transplant Society of Australia and New Zealand;East Mediterranean Blood and Marrow Transplantation Group;Sociedade Brasileira de Transplante de Medula Ossea

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造血细胞移植(HCT)技术和支持性治疗技术的进步已导致HCT后长期生存率的改善。新出现的移植适应症、引入新的移植物来源(例如脐带血)和使用强度较低的预处理方案移植老年患者也有助于HCT存活者数量的增加。这些幸存者有发生继发于移植前、移植中和移植后暴露和风险因素的晚期并发症的风险。2006年公布了对HCT幸存者进行筛查和预防的指导方针。2011年召集了一个国际移植专家小组,审查当代文献并更新建议,同时考虑不断变化的移植实践和这些指南的国际适用性。本综述提供了最新的建议,筛查和预防措施的儿童和成人幸存者的自体和同种异体HCT。
Advances in hematopoietic cell transplantation (HCT) technology and supportive care techniques have led to improvements in long-term survival after HCT. Emerging indications for transplantation, introduction of newer graft sources (e.g. umbilical cord blood) and transplantation of older patients using less intense conditioning regimens have also contributed to an increase in the number of HCT survivors. These survivors are at risk for developing late complications secondary to pre-, peri- and post-transplant exposures and risk-factors. Guidelines for screening and preventive practices for HCT survivors were published in 2006. An international group of transplant experts was convened in 2011 to review contemporary literature and update the recommendations while considering the changing practice of transplantation and international applicability of these guidelines. This review provides the updated recommendations for screening and preventive practices for pediatric and adult survivors of autologous and allogeneic HCT.
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