Age-Related Choroidal Atrophy
Age-Related Choroidal Atrophy
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DOI：
10.1016/j.ajo.2008.12.010
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发表时间：
2009-05-01
影响因子：
4.2
通讯作者：
Spaide, Richard F.
中科院分区：
文献类型：
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作者：
Spaide, Richard F.
目的：报道其新定义实体、年龄、相关脉络膜萎缩的临床特征。设计：回顾性观察性病例系列。方法：通过将光谱域光学相干断层扫描装置定位到足够靠近眼睛的位置以获得倒置图像，在图像中测量脉络膜厚度。在5 x 15度或更大的矩形内获得7个切片，每个切片由100个平均扫描组成，以涵盖黄斑和颞部并乳头视网膜。纳入脉络膜厚度小于125 μ m的患者，排除6屈光度及以上近视、有葡萄膜炎、外伤、电离辐射、光动力治疗、玻璃体内皮质类固醇注射或绒膜视网膜营养不良史的患者。评估患者的视力，黄斑外观和青光眼的存在。结果：17例患者28只眼符合条件，平均年龄80.6岁（标准差+/- 7.3岁）。所有眼睛眼底呈镶嵌状。平均中央凹下脉络膜厚度为69.8 μ m，鼻部更薄。在18只没有晚期年龄相关性黄斑变性（AMD）证据的眼睛中，平均视力为20/40，黄斑有色素变化，部分原因是脉络膜可能模仿早期AMD，黄斑下脉络膜血管稀疏。其余10只眼并发晚期AMD。青光眼6例（35.3%），均有乳头周围萎缩。在乳头周围萎缩的p区划分之前，脉络膜几乎消失。结论：年龄相关性脉络膜萎缩影响老年人，其后极异常的发展可能与AMD的典型表现相似，也与之相关。年龄相关性脉络膜萎缩的患者患青光眼的风险更高。[J]中华眼科杂志，2009;47(1):1-8。2009年，Elsevier Inc.发布。版权所有。)
PURPOSE: To report the clinical characteristics of it newly defined entity, age,related choroidal atrophy.DESIGN: Retrospective, observational case series.METHODS: The choroidal thickness was measured in images obtained by positioning a spectral-domain optical coherence tomography device close enough to the eye to acquire an inverted image. Seven sections each comprised of 100 averaged scans were obtained within a 5 x 15-degree or larger rectangle to encompass the macula and temporal juxtapapillary retina. The choroidal thickness of patients less than 125 mu m in thickness were included, whereas eyes with myopia of 6 diopters or more, a history of uveitis, trauma, ionizing radiation, photodynamic therapy, intravitreal corticosteroid injection, or tapetoretinal dystrophy were excluded. The patients were evaluated for Visual acuity, macular appearance, and the presence of glaucoma.RESULTS: There were 28 eligible eyes of 17 patients with a mean age 80.6 years (standard deviation, +/- 7.3 years). All eyes had a tessellated fundus appearance. The mean subfoveal choroidal thickness was 69.8 mu m and became even more attenuated nasally. Of the 18 eyes that had no evidence of late age-related macular degeneration (AMD), the mean Visual acuity was 20/40, there were pigmentary changes in the macula that arose in part from the choroid potentially mimicking early AMD, and a rarefaction of the choroidal vessels under the macula. Concurrent late AMD was found in the 10 remaining eyes. Glaucoma was present in 6 patients (35.3%), all of whom had peripapillary atrophy. The choroid was seen to become nearly obliterated before the demarcation of the P-zone of peripapillary atrophy.CONCLUSIONS: Age-related choroidal atrophy affects older individuals in whom posterior pole abnormalities develop that may mimic and also be associated with findings typical for AMD. Patients with age-related choroidal atrophy may be at higher risk for glaucoma. (Am J Ophthalmol 2009;147:801-810. Q 2009 by Elsevier Inc. All rights reserved.)