EFFICACY OF TRIMETHOPRIM, SULFAMETHOXAZOLE AND COMBINATION OF BOTH IN ACUTE URINARY-TRACT INFECTION - CLINICAL AND PHARMACOKINETICAL STUDIES
EFFICACY OF TRIMETHOPRIM, SULFAMETHOXAZOLE AND COMBINATION OF BOTH IN ACUTE URINARY-TRACT INFECTION - CLINICAL AND PHARMACOKINETICAL STUDIES
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DOI：
10.1159/000221470
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发表时间：
1973-01-01
期刊：
影响因子：
3.3
通讯作者：
KEWITZ, H
中科院分区：
文献类型：
--
作者：
KOCH, UJ;SCHUMANN, KP;KEWITZ, H
本文报告磺胺甲恶唑（SMZ）、甲氧苄啶（TMP）及两者联合应用（39例）治疗妇科大手术后急性尿路感染的疗效。在给药前第1天和第5天以及给药后4、7和12 h测定血浆TMP和SMZ浓度。TMP和TMP/SMZ之间无差异，尽管抗菌谱存在微小差异。由于副作用发生率较小，TMP单药治疗上级联合方案;因此，除了与SMZ联合治疗外，建议在市场上单独引入TMP。
The effectiveness of sulfamethoxazole (SMZ; 13 patients), trimethoprim (TMP; 23 patients), and the combination of both (39 patients) in therapy for acute urinary tract infections after major gynecological operations has been studied. Plasma concentrations of TMP and SMZ were measured on the 1st and 5th days of treatment before as well as 4, 7 and 12 h after administering the drugs. No difference was found between TMP and TMP/SMZ, although there are minor differences in the antibacterial spectrum. Treatment with TMP alone is superior to the combined regimen due to a smaller incidence of side effects; thus, in addition to the combination with SMZ, introduction of TMP alone on the market is recommended.