Resting state functional magnetic resonance imaging reveals distinct brain activity in heavy cannabis users - a multi-voxel pattern analysis.
Resting state functional magnetic resonance imaging reveals distinct brain activity in heavy cannabis users - a multi-voxel pattern analysis.
复制标题
静止状态功能磁共振成像揭示了重大麻使用者的不同大脑活动 - 多素模式分析。
DOI：
10.1177/0269881114550354
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Newman SD
中科院分区：
文献类型：
--
作者：
Cheng H;Skosnik PD;Pruce BJ;Brumbaugh MS;Vollmer JM;Fridberg DJ;O'Donnell BF;Hetrick WP;Newman SD
长期使用大麻会导致认知、知觉和人格改变，据信这与大脑区域变化和功能区域之间连接的可能变化有关。本研究旨在通过静息状态下的功能性磁共振成像扫描来识别这些变化。提出了一种两级多体素模式分析，以将男性大麻使用者与正常对照者进行分类。第一级分析在体素基础上工作，并识别用于第二级分析的输入的聚类，第二级分析在这些区域之间的功能连接上工作。我们发现男性大麻使用者在额中回、中央前回、上级额回、后扣带皮层、小脑和其他一些区域有明显的集群。基于这些聚类的功能连接性，实现了84-88%的分类准确率。高相关性也被发现之间的整体分类准确性和巴雷特-巴雷特冲动量表因子分数的注意力和运动。我们的研究结果表明，男性大麻使用者的大脑存在区域差异，从小脑到前额叶皮层，这与功能连接的差异有关。
Chronic cannabis use can cause cognitive, perceptual and personality alterations, which are believed to be associated with regional brain changes and possible changes in connectivity between functional regions. This study aims to identify the changes from resting state functional magnetic resonance imaging scans. A two-level multi-voxel pattern analysis was proposed to classify male cannabis users from normal controls. The first level analysis works on a voxel basis and identifies clusters for the input of a second level analysis, which works on the functional connectivity between these regions. We found distinct clusters for male cannabis users in the middle frontal gyrus, precentral gyrus, superior frontal gyrus, posterior cingulate cortex, cerebellum and some other regions. Based on the functional connectivity of these clusters, a high overall accuracy rate of 84–88% in classification accuracy was achieved. High correlations were also found between the overall classification accuracy and Barrett Barrett Impulsiveness Scale factor scores of attention and motor. Our result suggests regional differences in the brains of male cannabis users that span from the cerebellum to the prefrontal cortex, which are associated with differences in functional connectivity.
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影响因子：
4.8
作者：
Farkas I;Kalló I;Deli L;Vida B;Hrabovszky E;Fekete C;Moenter SM;Watanabe M;Liposits Z
通讯作者：
Liposits Z
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作者：
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通讯作者：
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