Prevalence and progression of cardiovascular calcifications in peritoneal dialysis patients: A prospective study
Prevalence and progression of cardiovascular calcifications in peritoneal dialysis patients: A prospective study
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DOI：
10.1016/j.bone.2012.06.002
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发表时间：
2012-09-01
期刊：
影响因子：
4.1
通讯作者：
Farina, Marco
中科院分区：
文献类型：
--
作者：
Gallieni, Maurizio;Caputo, Flavia;Farina, Marco
背景：透析患者可能存在血清钙、磷和甲状旁腺激素水平异常，并伴有相关的骨病。这一人群的死亡风险增加，心血管钙化（CC）是一个促成因素。腹膜透析患者出现高脂血症的风险增加，高脂血症是动脉粥样硬化斑块形成的一个促成因素。虽然有几项研究已经描述了CC的存在和进展，在血液透析人群中，有较少的数据在腹膜dialys.Study设计：肾性骨营养不良和钙化：腹膜透析（ROCK-PD）研究的关键因素是一个36个月，前瞻性观察研究在意大利进行。该研究检查了CC在两个心脏瓣膜和五个动脉部位的存在和进展。潜在的协会与死亡率和心血管疾病的发病率，人口统计学，临床和血液化学variables investigated.Results：CC是目前在77%的患者在基线（N=369）和90%的患者在研究结束（N=145），在73%的患者进展。有42例死亡（11%）。分析表明，基线P水平和左心室肥厚之间存在显著相关性。然而，有没有一致的相关性之间的血清钙或P与死亡率或发病率。结论：CC是常见的腹膜透析患者和进展中的大多数患者。(C)2012 Elsevier Inc. All rights reserved.
Background: Patients on dialysis may have abnormal serum levels of Ca, P and parathyroid hormone, with related bone diseases. This population has an increased risk of death, with cardiovascular calcification (CC) a contributing factor. Patients on peritoneal dialysis appear to be at increased risk of hyperlipidemia, a contributing factor to atherosclerotic plaque formation. Although several studies have described the presence and progression of CC in hemodialysis populations, there are fewer data in patients on peritoneal dialysis.Study design: The Renal Osteodystrophy and Calcifications: Key factors in Peritoneal Dialysis (ROCK-PD) study was a 36-month, prospective observational study conducted in Italy. The study examined the presence and progression of CC in two cardiac valves and five arterial sites. The potential associations of serum Ca and P with mortality and cardiovascular morbidity, demographic, clinical and blood chemistry variables was investigated.Results: CC was present in 77% of patients at baseline (N=369) and in 90% of patients by study end (N=145), progressing in 73% of patients. There were 42 deaths (11%). Analyses showed a marked correlation between baseline P levels and the presence of left ventricular hypertrophy. However, there were no consistent correlations between serum Ca or P with mortality or morbidity.Conclusions: CC was common in peritoneal dialysis patients and progressed in a majority of patients. (C) 2012 Elsevier Inc. All rights reserved.