Halo nevus: competent surveillance of potential melanoma?
Halo nevus: competent surveillance of potential melanoma?
复制标题
晕痣：对潜在黑色素瘤的有效监测？
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
B. Barna
中科院分区：
文献类型：
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作者：
J. Krebs;H. Roenigk;S. Deodhar;B. Barna
晕痣的组织学特征是致密的淋巴细胞浸润物包裹着复合性痣的细胞。临床上，痣在其周围的皮肤上形成一个脱色的外环(图)。雀斑本身通常会自发消失，脱色的光环通常会重新着色。对于良性肿瘤的自发消退现象，已有多种机制被解释。1科普曼等人最近的研究结果2表明循环抗体是晕痣消退的机制。这一结论是基于一些晕痣患者血清中对恶性黑色素瘤细胞胞浆的抗体的证明。免疫反应通过两种机制发生，细胞(T细胞)和体液(B细胞)。细胞免疫是肿瘤和移植排斥反应的主要原因，而不是体液免疫(抗体)。
The halo nevus is characterized histologically by a dense lymphocytic infiltrate enveloping the cells of a compound nevus. Clinically the nevus develops a depigmented outer ring in the skin surrounding it (Figure). The nevus itself often disappears spontaneously and the depigmented halo usually re-pigments. Numerous mechanisms have been postu-lated for this phenomenon of spontaneous regression of a benign tumor. 1 Results of recent studies by Copeman et al 2 implicated circulating antibody as the mechanism responsible for regression of the halo nevus. The conclusions are based on the demonstration of antibodies in the sera of some halo nevi patients to the cytoplasm of malignant melanoma cells. Immune response occurs by two mechanisms, cellular (T-cell) and humoral (B-cell). Cell-mediated immunity is primarily responsible for tumor and transplant rejection, not humoral immunity (anti-body).