Non-effective increase of fMRI-activation for motor performance in elder individuals
Non-effective increase of fMRI-activation for motor performance in elder individuals
复制标题
DOI：
10.1016/j.bbr.2011.04.040
复制
发表时间：
2011-10-01
影响因子：
2.7
通讯作者：
Lotze, M.
中科院分区：
文献类型：
--
作者：
Loibl, M.;Beutling, W.;Lotze, M.
运动表现随着年龄的增长而下降，有人提出老年人可能会通过增加大脑激活来弥补这些缺陷。然而，目前尚不清楚增加的激活--特别是对侧和同侧大脑半球的运动区域--是否可能有效地促进运动表现，或者这是否是抵消运动系统中与年龄相关的缺陷的无效方法。我们测试了这个问题的映射过程中表现出不同的要求运动任务在18个年轻人（平均25.39岁）和17个老年人（平均66.65岁）健康人的大脑激活。我们测试了广泛的手部运动任务，从被动手腕运动、不同频率的握拳到体感引导的手指捏捏任务。在老年组中，功能激活普遍增加的所有任务具有可比的运动性能同侧的主要和次要运动领域。年轻组显示出增加对侧初级运动皮层激活更困难的体感指导精确抓握任务。我们将高难度任务的运动表现与fMRI激活的表现相关联。老年参与者表现出负相关的同侧补充运动区（SMA）和同侧感觉运动皮层（SM 1）。年轻参与者显示对侧SMA和SM 1呈正相关。我们的数据表明，增加大脑招聘反映了一个与年龄相关的高难度任务的反应效率低下，并不是一个有效的方法来抵消与年龄相关的运动系统的缺陷。(C)2011 Elsevier B. V.保留所有权利。
Motor performance declines with increasing age and it has been proposed that elder people might compensate for these deficits with increased cerebral activation. However, it is not known, whether increased activation - especially in motor areas of the contralateral and the ipsilateral cerebral hemisphere - might effectively contribute to motor performance or whether it is an ineffective way to counteract age related deficits in the motor system. We tested this question by mapping brain activation during performance of differentially demanding motor tasks in 18 young (mean 25.39 years) and 17 elderly (mean 66.65 years) healthy individuals. We tested a wide range of hand motor tasks from passive wrist movements, fist clenching at different frequencies, to a somatosensory-guided finger pinch task. In the elderly group functional activation was generally increased for all tasks with comparable motor performance for ipsilateral primary and secondary motor areas. The young group showed increased contralateral primary motor cortex activation for the more difficult somatosensory guided precision grip task. We correlated motor performance of the task with high difficulty and comparable performance with fMRI-activation. Elder participants showed a negative correlation for the ipsilateral supplementary motor area (SMA) and for the ipsilateral sensorimotor cortex (SM1). Young participants showed a positive correlation for contralateral SMA and SM1. Our data suggest an increased cerebral recruitment reflects an inefficient response to an age-related higher difficulty of task and is not an effective way to counteract age-related deficits in the motor system. (C) 2011 Elsevier B.V. All rights reserved.