CircGNG4 Promotes the Progression of Prostate Cancer by Sponging miR-223 to Enhance EYA3/c-myc Expression.
CircGNG4 Promotes the Progression of Prostate Cancer by Sponging miR-223 to Enhance EYA3/c-myc Expression.
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CircGNG4 通过海绵 miR-223 增强 EYA3/c-myc 表达促进前列腺癌的进展
DOI：
10.3389/fcell.2021.684125
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发表时间：
2021
影响因子：
5.5
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Xu S;Lian Z;Zhang S;Xu Y;Zhang H
诊断为前列腺癌的患者通常预后不良，治疗选择有限，因为具体的发病机制仍有待阐明。Circular RNA（circRNA）是一类与microRNA（miRNA/miR）和转录因子相互作用以调节基因表达的非编码RNA。然而，对在前列腺癌发病机制中起作用的特定circRNA知之甚少。本研究的发现证实了circRNA G蛋白亚基γ 4（circGNG 4）在前列腺癌组织和细胞系中上调。敲低circGNG 4可抑制前列腺癌细胞的恶性行为。此外，使用生物信息学来预测circGNG 4或miR-223与EYA转录共激活因子和磷酸酶3（EYA 3）/c-Myc mRNA之间的靶向相互作用。miR-223抑制前列腺癌细胞的恶性行为，而EYA 3/c-Myc则具有相反的作用。circGNG 4通过海绵状作用于miR-223而增强EYA 3/c-Myc的表达，从而促进体内前列腺癌肿瘤的生长。综上所述，circGNG 4/miR-223/EYA 3/c-Myc调控通路促进了前列腺癌的恶性进展。本研究结果可能为前列腺癌的诊断或治疗提供潜在的新靶点。
Patients diagnosed with prostate cancer often have a poor prognosis and limited treatment options, as the specific pathogenesis remains to be elucidated. Circular RNA (circRNA) is a type of non-coding RNA that interacts with microRNA (miRNA/miR) and transcription factors to regulate gene expression. However, little is known about specific circRNAs that serve roles in the pathogenesis of prostate cancer. Findings of the present study confirmed that circRNA G protein subunit γ 4 (circGNG4) was upregulated in prostate cancer tissues and cell lines. Knockdown of circGNG4 inhibited the malignant behavior of prostate cancer cells. Furthermore, bioinformatics were used to predict targeting interactions between circGNG4 or miR-223 and EYA transcriptional coactivator and phosphatase 3 (EYA3)/c-Myc mRNA. miR-223 inhibited the malignant behavior of prostate cancer cells, while EYA3/c-Myc had the opposite effect. circGNG4 enhanced the expression of EYA3/c-Myc by sponging miR-223 to promote the growth of prostate cancer tumors in vivo. In conclusion, the circGNG4/miR-223/EYA3/c-Myc regulatory pathway promoted the malignant progression of prostate cancer. The results of the present study may provide potential new targets for the diagnosis or treatment of prostate cancer.
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