MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients
MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients
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DOI：
10.1182/blood-2004-10-3982
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发表时间：
2005-08-15
期刊：
影响因子：
20.3
通讯作者：
Coates, TD
中科院分区：
文献类型：
--
作者：
Wood, JC;Enriquez, C;Coates, TD
肝铁浓度(HIC)的测定是预测输血铁负荷和输血依赖性贫血患者长期预后的重要指标。这项工作的目标是开发一种易于获得的、非侵入性的临床HIC测量方法。磁共振成像(MRI)测量的松弛速率R2(1/T2)和R2*(1/T2*)对HIC的估计有不同的优势。这篇文章比较了使用优化的R2和R2*方法在102名铁超载患者和13名对照组中的无创铁估计。在铁超负荷组中，22名患者同时接受了肝脏活检。在HICs为1.33~32.9 mg/g范围内，R2和R2*与HIC密切相关(r(2)=0.95)，但R2与HIC呈曲线关系。重要的是，R2校准曲线与其他研究人员生成的曲线相似，尽管在技术和仪器方面存在显著差异。联合测量R2和R2*并不能产生比单独测量更准确的结果。通过适当的MRI采集技术，R2和R2*都可以准确地测量HIC临床相关范围内的肝铁浓度。
Measurements of hepatic iron concentration (HIC) are important predictors of transfusional iron burden and long-term outcome in patients with transfusion-dependent anemias. The goal of this work was to develop a readily available, noninvasive method for clinical HIC measurement. The relaxation rates R2 (1/T2) and R2* (1/T2*) measured by magnetic resonance imaging (MRI) have different advantages for HIC estimation. This article compares noninvasive iron estimates using both optimized R2 and R2* methods in 102 patients with iron overload and 13 controls. In the iron-overloaded group, 22 patients had concurrent liver biopsy. R2 and R2* correlated closely with HIC (r(2) >= .95) for HICs between 1.33 and 32.9 mg/g, but R2 had a curvilinear relationship to HIC. Of importance, the R2 calibration curve was similar to the curve generated by other researchers, despite significant differences in technique and instrumentation. Combined R2 and R2* measurements did not yield more accurate results than either alone. Both R2 and R2* can accurately measure hepatic iron concentration throughout the clinically relevant range of HIC with appropriate MRI acquisition techniques.