Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain
Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain
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DOI：
10.1016/s0925-4773(98)00218-4
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发表时间：
1999-02-01
影响因子：
2.6
通讯作者：
Gruss, P
中科院分区：
文献类型：
--
作者：
Ashery-Padan, R;Alvarez-Bolado, G;Gruss, P
果蝇基因四关节（fj）编码一种分泌的或细胞表面的蛋白质，对腿和翅膀的生长和分化以及眼睛的正常发育很重要。在这里，我们报告的小鼠四点基因（fjx 1）的克隆和它的表达模式在胚胎发育和成人的大脑。在神经板中，fjx 1在假定的前脑和中脑中表达，并且在菱形节4中表达，然而，前脑的小的吻侧/内侧区域;原基没有表达。fjx 1在神经管中的表达可分为三个阶段。(1)在胚胎脑中，fjx 1在两块神经上皮中表达：中脑顶盖和端脑囊泡。(2)在胎儿和出生后早期的大脑中，fjx 1主要由分层端脑结构的原基表达：皮质（脑室层和皮质板），嗅球（室管膜下层和二尖瓣细胞层）。此外，在上级丘中观察到表达。(3)在成人中，fjx 1由均匀分布在端脑（等皮质，纹状体，海马，嗅球，梨状皮质），小脑浦肯野细胞层和许多髓核中的神经元表达。在胚胎中，在前肢和后肢的顶端外胚层脊和鳃弓的外胚层中可以进一步看到强表达。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
The Drosophila gene four jointed (fj) codes for a secreted or cell surface protein important for growth and differentiation of legs and wings and for proper development of the eyes. Here we report the cloning of the mouse four-pointed gene (fjx1) and its pattern of expression in the brain during embryogenesis and in the adult. In the neural plate, fjx1 is expressed in the presumptive forebrain and midbrain, and in rhombomere 4, however a small rostral/medial area of the forebrain; primordium is devoid of expression. Expression of fjx1 in the neural tube can be divided into three phases. (1) In the embryonic brain fjx1 is expressed in two patches of neuroepithelium: in the midbrain tectum and the telencephalic vesicles. (2) In fetal and early postnatal brain fjx1 is expressed mainly by the primordia of layered telencephalic structures: cortex (ventricular layer and cortical plate), olfactory bulb (subependymal layer and in the mitral cell layer). In addition expression is observed in the superior colliculus. (3) In the adult, fjx1 is expressed by neurons evenly distributed in the telencephalon (isocortex, striatum, hippocampus, olfactory bulb, piriform cortex), in the Purkinje cell layer of the cerebellum, and numerous medullary nuclei. In the embryo, strong expression can further be seen in the apical ectodermal ridge of fore- and hindlimbs and in the ectoderm of the branchial arches. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.