The fbpABC locus of Neisseria gonorrhoeae functions in the periplasm-to-cytosol transport of iron
The fbpABC locus of Neisseria gonorrhoeae functions in the periplasm-to-cytosol transport of iron
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DOI：
10.1128/jb.178.7.2145-2149.1996
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发表时间：
1996-04-01
影响因子：
3.2
通讯作者：
Mietzner, TA
中科院分区：
文献类型：
--
作者：
Adhikari, P;Berish, SA;Mietzner, TA
我们已经确定，淋球菌fbp基因下游的DNA序列包含两个开放的阅读框：一个指定的fbpB，它编码一种蛋白质，建议作为一个细胞质通透酶的功能，和一个指定的fbpC，它编码一种蛋白质，建议作为一个核苷酸结合蛋白的功能。fpbABC操纵子组成的铁转运系统，是同源的sfu和命中操纵子先前报道的粘质沙雷氏菌和流感嗜血杆菌，分别显示元素的ATP结合盒转运。fpbABC操纵子与这些位点的不同之处在于，当在大肠杆菌中过表达时，它是致命的。
We have determined that the DNA sequence downstream of the well-characterized gonococcal fbp gene contains two open reading frames: one designated fbpB, which encodes a protein proposed to function as a cytoplasmic permease, and one designated fbpC, which encodes a protein proposed to function as a nucleotide-binding protein. The fpbABC operon composes an iron transport system that is homologous to the sfu and hit operons previously reported for Serratia marcescens and Haemophilus influenzae, respectively, and displays elements characteristic of ATP binding cassette transporters. The fpbABC operon differs from these loci in that it is lethal when overexpressed in Escherichia coli.