Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma.
Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma.
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TMEM100的新作用：抑制肝细胞癌的转移和增殖
DOI：
10.18632/oncotarget.3954
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发表时间：
2015-07-10
期刊：
影响因子：
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通讯作者：
Yang L
中科院分区：
文献类型：
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作者：
Ou D;Yang H;Hua D;Xiao S;Yang L
跨膜蛋白100（TMEM 100）通过ALK 1/TGF-β信号传导被激活。我们发现TMEM 100在肝细胞癌（HCC）组织和高转移细胞系中降低。过表达TMEM 100抑制细胞的侵袭、迁移和增殖。低水平的TMEM 100与肝硬化、肿瘤大小、肿瘤结节数、TNM分期、BCLC分期、Edmondson-Steiner分期和静脉侵犯相关。此外，TMEM 100是总生存期（P = 0.03）和无病生存期（P = 0.019）的独立风险因素。目前的研究结果表明，TMEM 100在HCC转移和增殖中起肿瘤抑制剂的作用。
Transmembrane protein 100 (TMEM100) was activated by ALK1/TGF-β signaling. We found that TMEM100 was decreased in hepatocellular carcinoma (HCC) tissues and in highly metastatic cell lines. Overexpressed of TMEM100 inhibited invasion, migration and proliferation. Low levels of TMEM100 were associated with cirrhosis, tumor size, Tumor nodule number, TNM stage, BCLC stage, Edmondson-Steiner Stage and vein invasion. Furthermore, TMEM100 was an independent risk factor for overall survival (P = 0.03) and disease-free survival (P = 0.019). The current findings suggest that TMEM100 functions as a tumor suppressor in HCC metastasis and proliferation.