The NLRP3 inflammasome, a target for therapy in diverse disease states
The NLRP3 inflammasome, a target for therapy in diverse disease states
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DOI：
10.1002/eji.200940162
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发表时间：
2010-03-01
影响因子：
5.4
通讯作者：
McDermott, Michael F.
中科院分区：
文献类型：
--
作者：
Cook, Graham P.;Savic, Sinisa;McDermott, Michael F.
NLRP3炎性小体在复发性和慢性炎症中的作用最初是在一组罕见的自身炎症条件下被描述的，称为冷冻素相关周期综合征。随后，炎性小体与许多常见疾病的病理有关，包括癌症、痛风和糖尿病。尽管有不同的病理，炎性小体在先天防御和肿瘤消除中的核心作用提示了在适当的地方减少炎症的共同治疗方法。
A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin-associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. Despite diverse pathologies, the central role of the inflammasome in innate defences and tumour elimination suggests common therapeutic approaches to reduce inflammation where appropriate.