THE COMPARATIVE DISTRIBUTION OF FOREBRAIN RECEPTORS FOR NEUROHYPOPHYSEAL PEPTIDES IN MONOGAMOUS AND POLYGAMOUS MICE
THE COMPARATIVE DISTRIBUTION OF FOREBRAIN RECEPTORS FOR NEUROHYPOPHYSEAL PEPTIDES IN MONOGAMOUS AND POLYGAMOUS MICE
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DOI：
10.1016/0306-4522(91)90321-e
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发表时间：
1991-01-01
期刊：
影响因子：
3.3
通讯作者：
SHAPIRO, LE
中科院分区：
文献类型：
--
作者：
INSEL, TR;GELHARD, R;SHAPIRO, LE
最近的几项研究表明，神经垂体肽催产素可能在大脑中起着介导各种形式的亲和行为的作用。 由于催产素功能的调节可能在很大程度上取决于其膜结合受体的数量和分布，我们研究了催产素受体分布在两个Peromyscus物种选择的亲和行为的差异。 使用选择性催产素受体配体[I-125]d（CH 2）5[Tyr（Me）2，Tyr-NH 2（9）]OVT（[I-125]OTA）的体外受体放射自显影术，我们比较了一夫多妻的物种Maniculatus Peromyscus和一夫一妻的物种California Peromyscus。 [I-125]OTA分布的显著种属差异在几个脑区明显，包括嗅觉通路、终纹床核、杏仁核、背外侧隔和几个皮质区。 此外，结合模式的性别差异在几个地区是明显的，主要是由于一夫多妻的物种，P. maniculatus的性二型模式。 为了进一步比较这些物种，在用于[I-125]OTA的替代切片中评估[H-3]精氨酸-加压素拮抗剂的结合。相对于催产素受体，与精氨酸-加压素受体的结合显示较少的物种差异，尽管一夫一妻制物种似乎在新皮层和侧隔中具有更多的精氨酸-加压素受体。 催产素受体分布的显着差异与其他啮齿动物的早期研究一致，表明催产素可能在介导物种典型的社会关系模式中发挥重要作用。
Several recent studies have suggested that the neurohypophyseal peptide oxytocin may have a role within the brain to mediate various forms of affiliative behavior. As the regulation of oxytocin function may be largely determined by the number and distribution of its membrane bound receptor, we investigated oxytocin receptor distribution in two Peromyscus species selected for differences in affiliative behavior. Using in vitro receptor autoradiography with the selective oxytocin receptor ligand [I-125]d(CH2)5[Tyr(Me)2,Tyr-NH2(9)]OVT ([I-125]OTA), we compared Peromyscus maniculatus, a polygamous species, to Peromyscus californicus, a monogamous species. Marked species differences in the distribution of [I-125]OTA were apparent in several brain areas, including olfactory pathways, bed nucleus of the stria terminalis, amygdala, dorsal lateral septum, and several cortical regions. In addition, gender differences in the binding pattern were evident in several regions, mostly due to sexually dimorphic patterns in the polygamous species, P. maniculatus. To further compare these species, the binding of a [H-3]arginine-vasopressin antagonist was assessed in alternate sections from those used for [I-125]OTA.Relative to oxytocin receptors, binding to arginine-vasopressin receptors showed fewer species differences, although the monogamous species appeared to have more arginine-vasopressin receptors in the neocortex and lateral septum. The striking differences in oxytocin receptor distribution are consistent with earlier studies in other rodents, suggesting that oxytocin may have an important role for mediating species-typical patterns of social affiliation.