Resistance patterns of selected respiratory tract pathogens in Poland.
Resistance patterns of selected respiratory tract pathogens in Poland.
复制标题
波兰选定呼吸道病原体的耐药模式。
DOI：
--
复制
发表时间：
2007
影响因子：
14.2
通讯作者：
W. Hryniewicz
中科院分区：
文献类型：
--
作者：
A. Skoczyńska;M. Kadłubowski;I. Waśko;J. Fiett;W. Hryniewicz
本研究介绍了2002-2004年期间波兰社区获得性呼吸道感染主要病原体对抗菌药物体外敏感性的调查结果。收集的1184株细菌分离株包括398株肺炎链球菌、344株流感嗜血杆菌、302株化脓性链球菌和140株卡他莫拉菌。在肺炎球菌分离株中，16.8%为青霉素不敏感（PNSP），其中80.6%被鉴定为多重耐药。总的来说，H.流感病毒分离株为β-内酰胺酶阳性，尽管这一百分比在研究的第三年显著增加。PCR结果显示，12.8%的H.流感病毒分离株被鉴定为低水平β-内酰胺酶阴性、氨苄青霉素耐药（BLNAR），1株分离株被鉴定为低水平β-内酰胺酶阳性、阿莫西林-克拉维酸耐药（BLPACR）。脉冲场凝胶电泳（PFGE）分类为45 H。将具有改变的青霉素结合蛋白的流感分离株分成15种PFGE类型，包括两种主要类型（具有四种和六种亚型），分别含有15种和10种分离株。对四环素、红霉素和克林霉素耐药率分别为20.9%、8.9%和4.6%。化脓性链球菌分离株。产β-内酰胺酶的M.卡他分离物。总之，尽管完全耐药分离株的比例明显增加，但波兰PNSP的总体发生率保持稳定。在波兰分离的H.流感。
This study presents the results of a survey of the in-vitro susceptibility to antimicrobial agents of major pathogens responsible for community-acquired respiratory tract infections in Poland during 2002-2004. The collection of 1184 bacterial isolates comprised 398 Streptococcus pneumoniae, 344 Haemophilus influenzae, 302 Streptococcus pyogenes and 140 Moraxella catarrhalis. Among the pneumococcal isolates, 16.8% were penicillin-non-susceptible (PNSP), of which 80.6% were identified as multidrug-resistant. Overall, 9.0% of H. influenzae isolates were beta-lactamase-positive, although this percentage increased noticeably in the third year of the study. Based on PCR results, 12.8% of H. influenzae isolates were identified as low-level beta-lactamase-negative, ampicillin-resistant (BLNAR), and one isolate as low-level beta-lactamase-positive, amoxycillin-clavulanic acid-resistant (BLPACR). Pulsed-field gel electrophoresis (PFGE) classified 45 H. influenzae isolates with altered penicillin-binding proteins into 15 PFGE types, including two predominant types (with four and six sub-types) containing 15 and ten isolates, respectively. Resistance to tetracycline, erythromycin and clindamycin was found in 20.9%, 8.9% and 4.6% of S. pyogenes isolates, respectively. The production of beta-lactamase characterised 91.4% of M. catarrhalis isolates. In summary, the overall occurrence of PNSP in Poland remains stable, although there was a noticeable increase in the proportion of fully-resistant isolates. A rising trend in the prevalence of beta-lactamase producers and low-level BLNAR isolates was observed among Polish isolates of H. influenzae.