CIRCULATING IMMUNE-COMPLEXES AND IMMUNOGLOBULIN-A RHEUMATOID-FACTOR IN PATIENTS WITH MESANGIAL IMMUNOGLOBULIN-A NEPHROPATHIES
CIRCULATING IMMUNE-COMPLEXES AND IMMUNOGLOBULIN-A RHEUMATOID-FACTOR IN PATIENTS WITH MESANGIAL IMMUNOGLOBULIN-A NEPHROPATHIES
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DOI：
10.1172/jci112522
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发表时间：
1986-06-01
影响因子：
15.9
通讯作者：
MESTECKY, J
中科院分区：
文献类型：
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作者：
CZERKINSKY, C;KOOPMAN, WJ;MESTECKY, J
48%的伊加肾病患者循环免疫复合物（CIC）中含有伊加和C3升高; IgA 1是主要亚类。IgA 1-IgG CIC检出率为44%，IgA 2-IgG CIC检出率为7%，IgM-IgA 1 CIC检出率为16%。未检测到IgM-IgA 1 CIC。蔗糖梯度离心表明IgG-IgA 1 CIC主要为中等大小（13- 19 S），而IgA 1-C3 CIC主要为11 - 19 S。在酸性pH下，分离的CIC显示存在大量的7S伊加。三分之一的患者血清伊加类风湿因子（RF）的聚合物和单体形式的升高，尽管正常水平的IgM-RF; 87%的IgA-RF升高的患者有IgA-IgG CIC。结果表明，伊加肾病患者CIC的IgA 1组分不一定是粘膜起源，并表明这些CIC的一部分由伊加RF与自体IgG免疫复合物组成。
Circulating immune complexes (CIC) containing IgA and C3 were elevated in 48% of IgA nephropathy patients; IgA1 was the predominant subclass. IgA1-IgG CIC were detected in 44%, IgA2-IgG CIC in 7%, and IgM-IgA1 CIC in 16% of the patients. No IgM-IgA1 CIC were detectable. Sucrose gradient ultracentrifugation indicated that IgG-IgA1 CIC were predominantly of intermediate (13-19S) size whereas IgA1-C3 CIC sedimented from 11S to 19S. At acid pH, isolated CIC revealed the presence of substantial amounts of 7S IgA. One third of the patients had elevated serum IgA rheumatoid factor (RF) of both polymeric and monomeric forms despite normal evels of IgM-RF; 87% of patients with elevated IgA-RF had IgA-IgG CIC. The results indicate that the IgA1 component of CIC in patients with IgA nephropathy is not necessarily of mucosal origin and suggest that a portion of these CIC consists of IgA RF immunologically complexed with autologous IgG.