Therapy of osteoporosis with calcium and vitamin D
Therapy of osteoporosis with calcium and vitamin D
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DOI：
10.1359/jbmr.07s209
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发表时间：
2007-12-01
影响因子：
6.2
通讯作者：
Bischoff-Ferrari, Heike A.
中科院分区：
文献类型：
--
作者：
Dawson-Hughes, Bess;Bischoff-Ferrari, Heike A.
维生素D和钙的摄入不足会导致钙吸收减少，骨重建率升高，骨丢失增加。维生素D不足也与肌肉功能下降和跌倒风险增加有关。性能和肌肉效应的机制还不清楚。在一些试验中，对维生素D不足的人给予维生素D可降低骨折率，但在其他试验中则不然。本报告的目的是（1）研究钙和维生素D如何协同工作，（2）考虑增加维生素D摄入量将影响福尔斯和骨折风险的关键证据，（3）估计达到最大骨折保护所需的25-羟基维生素D [25（OH）D]水平。
Inadequate intakes of vitamin D and calcium lead to reduced calcium absorption, higher bone remodeling rates, and increased bone loss. Vitamin D insufficiency has also been linked to reduced muscle function and increased risk of falling. The mechanisms for the performance and muscle effects are not well understood. Administering vitamin D to those with inadequate vitamin D status has been shown to lower fracture rates in some trials but not in others. The purpose of this presentation is (1) to examine how calcium and vitamin D work in concert, (2) to consider key evidence that increasing vitamin D intake will affect risk of falls and fractures, and (3) to estimate the 25-hydroxyvitamin D [25(OH)D] level needed to achieve maximum fracture protection.