STUDY OF SCHISTOSOMA-MANSONI TRANSFERRED INTO PERMISSIVE AND NONPERMISSIVE HOSTS
STUDY OF SCHISTOSOMA-MANSONI TRANSFERRED INTO PERMISSIVE AND NONPERMISSIVE HOSTS
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DOI：
10.1016/0020-7519(77)90038-8
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发表时间：
1977-01-01
影响因子：
4
通讯作者：
SENFT, AW
中科院分区：
文献类型：
--
作者：
CIOLI, D;KNOPF, PM;SENFT, AW
研究了从小鼠移植到大鼠体内或从大鼠移植到仓鼠体内的曼氏血吸虫的存活、生长和产卵能力。大鼠体内的蠕虫发育不良，局限于肝脏，只会产下少量不能受精的卵。当移植到仓鼠体内时，它们的大小增加，在肠系膜静脉中定位，并在移植后3周内产生接近正常仓鼠生长的蠕虫的卵。当将成年小鼠蠕虫注射到大鼠体内时，它们的大小会缩小，留在肝脏中，并产生少量发育不完全的卵。这些研究表明，蠕虫的生理和生殖状况受到宿主的强烈影响。在非受纳宿主（大鼠）中，生长和产卵的抑制不是永久性的，因为在转移到受纳宿主（仓鼠）时，发育不良的蠕虫可以恢复生长和产卵。
The survival, growth and egg laying capacity of S. mansoni worms surgically transplanted from mice into rats or from rats into hamsters was studied. Worms in the rat are stunted, remain localized in the liver and lay non-fertile eggs in small numbers. When transferred to the hamster, they increase in size, localize in the mesenteric veins and produce numbers of eggs approaching normal hamster-grown worms within 3 wk following transplantation. When adult mouse worms are injected into rats, they regress in size, remain in the liver and produce small numbers of incompletely developed eggs. These studies indicate that the physiological and reproductive status of the worm is strongly influenced by the host. In the nonpermissive host (the rat), the suppression of growth and egg laying is not permanent, since on transfer into a permissive environment (the hamster), stunted worms can resume growth and oviposition.