DNA ANEUPLOIDY IN COLONIC BIOPSIES PREDICTS FUTURE-DEVELOPMENT OF DYSPLASIA IN ULCERATIVE-COLITIS
DNA ANEUPLOIDY IN COLONIC BIOPSIES PREDICTS FUTURE-DEVELOPMENT OF DYSPLASIA IN ULCERATIVE-COLITIS
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DOI：
10.1016/0016-5085(92)91185-7
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发表时间：
1992-11-01
期刊：
影响因子：
29.4
通讯作者：
RABINOVITCH, PS
中科院分区：
文献类型：
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作者：
RUBIN, CE;HAGGITT, RC;RABINOVITCH, PS
本研究的目的是确定溃疡性结肠炎（UC）患者结肠活检标本中异常上皮DNA含量（非整倍体）是否与组织学进展至异型增生相关并预测其发展。在20例低癌症风险患者中不存在非整倍体。在81例高癌症风险患者中，非整倍体与组织学异常的严重程度（阴性、不确定、异型增生或癌症）显著相关。我们的数据表明，从统计学上看，需要比通常更多的活检标本来检测局灶性发育不良病变。对25例无异型增生的高危患者进行的前瞻性研究显示，5例非整倍体患者均在1-2.5年内进展为异型增生，而19例无非整倍体患者在2-9年内未进展为非整倍体或异型增生。我们的数据表明，粘膜活检标本中的非整倍体与组织学分级相关，并确定了一个子集的患者没有异型增生谁是更有可能发展it. It的结论是，更频繁和广泛的结肠镜监测这一少数子集的高风险患者和不太频繁的监测，在其余大多数可能会降低成本和检测更多的可治愈的病变。
The objective of the present study was to determine whether abnormal epithelial DNA content (aneuploidy) in colonic biopsy specimens from ulcerative colitis (UC) patients correlated with and predicted histological progression to dysplasia. Aneuploidy was absent in 20 low-cancer risk patients. In 81 high-cancer risk patients aneuploidy correlated significantly with the severity of histological abnormality (negative, indefinite, dysplasia, or cancer). Statistically our data suggest that many more biopsy specimens than are usually taken are needed to detect focal dysplastic lesions. Prospective study of 25 high risk patients without dysplasia revealed 5 with aneuploidy, all of whom progressed to dysplasia in 1–2.5 years, whereas 19 patients without aneuploidy did not progress to either aneuploidy or dysplasia within 2–9 years. Our data indicate that aneuploidy in mucosal biopsy specimens correlates with histological grade and identifies a subset of patients without dysplasia who are more likely to develop it. It was concluded that more frequent and extensive colonoscopic surveillance of this minority subset of high risk patients and less frequent surveillance in the remaining majority may reduce cost and detect more curable lesions.