Y-box binding protein 1 expression in gastric cancer subtypes and association with cancer neovasculature
Y-box binding protein 1 expression in gastric cancer subtypes and association with cancer neovasculature
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Y-box结合蛋白1在胃癌亚型中的表达及其与癌症新生血管的关联
DOI：
10.1007/s12094-014-1208-4
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发表时间：
2015-02-01
影响因子：
3.4
通讯作者：
Kohno, K.
中科院分区：
文献类型：
--
作者：
Wu, Y.;Wang, K. -Y.;Kohno, K.
目的Y盒结合蛋白1(YB-1)在肿瘤细胞中的表达与多种肿瘤的恶性进展和预后不良密切相关。最近，我们证实YB-1在肿瘤细胞中的表达是判断胃癌患者预后和肝转移的免疫标志物，并证实YB-1是肿瘤中血管生成和增殖的内皮细胞的良好生物标志物。方法采用免疫组织化学方法检测YB-1在胃癌组织中的表达。结果YB-1在胃癌组织中的表达与肿瘤的Lauren分型、JGCA分期、血管侵犯程度及微血管密度有显著差异(P=0.018，P=0.002，P<；P=0.001，P<；0.001)。癌细胞YB-1的表达与肿瘤的TNM分期和淋巴侵犯无关。而血管内皮细胞YB-1的表达与肿瘤的N分期、M分期、TNM分期和微血管密度显著相关(P<；分别为0.001，P=0.013，P=0.001和P<；0.001)。值得注意的是，在肿瘤血管中表达YB-1的病例中，YB-1在癌细胞中也有表达(P=0.040)。结论YB-1可能通过其在癌细胞和癌细胞中的作用促进胃癌的发生，是一种潜在的肿瘤标志物。
PurposeY-box binding protein 1 (YB-1) expression in cancer cells is closely associated with malignant progression and poor prognosis in various cancers. Recently, we demonstrated that YB-1 expression in cancer cells is an immunomarker for patient prognosis and liver metastasis of gastric cancer (GC), and identified YB-1 as an excellent biomarker of angiogenic and proliferating endothelial cells in cancers. We further explored the expression patterns of YB-1 in gastric vasculature and the relationship with the clinical pathologic characteristics, as well as YB-1 phenotype in cancer cells.Methods/PatientsImmunohistochemical analysis of YB-1 was performed using 163 surgically resected primary GC specimens.ResultsYB-1 expression in cancer cells significantly differed with respect to Lauren type, JGCA classification, vascular invasion (VI), and microvessel density (MVD) of cancers (P= 0.018,P= 0.002,P< 0.001, andP< 0.001, respectively). No correlation was found between cancer-cell YB-1 expression and TNM stage or lymphatic invasion. However, YB-1 expression in vascular endothelial cells significantly correlated with N stage, M stage, TNM stage, and MVD of cancers (P< 0.001,P= 0.013,P< 0.001, andP< 0.001, respectively). Notably, cases with YB-1 expression in cancer vasculature also demonstrated YB-1 expression in cancer cells (P= 0.040).ConclusionsYB-1 may promote GC development through its function in both cancer cells and cancer vascular cells, and thus represent a potential biomarker in this disease.