Porphyromonas gingivalis adopts intricate and unique molecular mechanisms to survive and persist within the host: a critical update
Porphyromonas gingivalis adopts intricate and unique molecular mechanisms to survive and persist within the host: a critical update
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DOI：
10.1080/20002297.2020.1801090
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发表时间：
2020-01-01
影响因子：
4.5
通讯作者：
Sivaraman, Karthik
中科院分区：
文献类型：
--
作者：
Chopra, Aditi;Bhat, Subraya G.;Sivaraman, Karthik
Porphyromonas。牙龈假单胞菌（牙龈假单胞菌）是一种专性的、能解糖的革兰氏阴性细菌，通常与牙周和全身炎症增加有关。已知牙龈菌可以在宿主组织中存活并持续存在，因为它通过改造其环境或改变宿主的免疫反应来调节整个生态系统。它与多种宿主受体相互作用，改变炎症、补体系统、细胞周期和细胞凋亡的信号通路。随着病原菌种类的出现，牙龈炎甚至可以诱导宿主及其附近其他微生物的自杀性细胞死亡。近年来，人们对p的分子免疫机制和毒力因子有了新的认识。已经发现，牙龈病可以增加其在宿主体内存活和免疫逃避的机会。因此，本文旨在提供新的复杂和独特的分子机制和毒力因素的综合更新。牙龈病与其在宿主体内的生存、持续和免疫逃避有关。
Porphyromonas. gingivalis (P. gingivalis) is an obligate, asaccharolytic, gram-negative bacteria commonly associated with increased periodontal and systemic inflammation.P. gingivalisis known to survive and persist within the host tissues as it modulates the entire ecosystem by either engineering its environment or modifying the host's immune response. It interacts with various host receptors and alters signaling pathways of inflammation, complement system, cell cycle, and apoptosis.P. gingivalisis even known to induce suicidal cell death of the host and other microbes in its vicinity with the emergence of pathobiont species. Recently, new molecular and immunological mechanisms and virulence factors ofP. gingivalisthat increase its chance of survival and immune evasion within the host have been discovered. Thus, the present paper aims to provide a consolidated update on the new intricate and unique molecular mechanisms and virulence factors ofP. gingivalisassociated with its survival, persistence, and immune evasion within the host.